BACKGROUND Anxiety and depression are more prevalent in women with polycystic ovary syndrome (PCOS) than in those without this disorder. Possible confounding effects of overweight and obesity are suggested. The aim was to compare symptoms of anxiety and depression in women with PCOS and controls matched for age, body weight and body mass index (BMI). METHODS Women with PCOS (n = 30) and contr...

To evaluate the re lat ionship be tween tumor burden and c i rculat ing immune complexes (IC) in ch i ldren with neurob lastoma (NBL), we studied sera col lected at intervals from pat ients with d isseminated (Stage III or IV) NBL. Sera from 10 of 12 pat ients conta ined IC by the Raji cell assay at some time dur ing the first 9 to 11 months of the study. H igher IC levels were observed in sera...

Abstract Vitiligo is a chronic autoimmune disease that targets melanocytes, causing skin depigmentation. Disease pathogenesis largely regulated by interferon-? activation of the Janus kinase (JAK) signalling pathway. A cream formulation JAK1/JAK2 inhibitor ruxolitinib demonstrated substantial re-pigmentation in two randomized, double-blind, vehicle-controlled phase 3 studies adults and adolesce...

Antibody  based  methods  have  numerous  advantages  compared  to  other  detection  methods. However, heavy metals cannot stimulate the immune antibody response; it is the main obstacle for preparation of the antibodies that used in detection methods of the metals. The production of the immunogenic Pb complexes by using cost benefit linkers of EDTA and DTPA were investigated in this  study.BS...

We examined the role of antigenic charge on the deposition of immune complexes (IC) in murine gloerulia Acute serum sickens nephritis was induced by injecting chemically modified cationic bovine serum albumin (cationic BSA). Controls were immunized with unmodified native BSA (native BSA), All mice were given a primary intraperitoneal immunization with 500 pg of the respective antigens plus Freu...

The understanding of the interaction of nanomaterials with relevant biological targets e.g., proteins is of paramount importance in biological and pharmaceutical fields of research. In a biological fluid, proteins can associate with nanomaterials which can subsequently exert a significant impact on the conformation and functionality of the protein. Here we report the binding interaction of a mo...

The present study was conducted to test the post-thaw sperm characteristics (motility, viability, acrosomal and plasma membranes integrity) through addition of different concentrations of BSA (0.50, 1.00, 5.00, 10.00 and15.00 %) to semen diluents lacking egg yolk. Semen was collected from four mature buffalo bulls, twice weekly using artificial vagina. Sperm characteristics (motility, viability...

The cytochrome P450 (P450)-dependent conversion of phenytoin (PHT) to p-hydroxy phenytoin (pHPPH), and tolbutamide (TLB) to 4-hydroxy tolbutamide (hydroxy-TLB), in human liver microsomes was studied in the presence of increasing concentrations (0-4%) of bovine serum albumin (BSA). Therefore, the free fraction (f(u)) of PHT and TLB varied. Whereas the f(u) of PHT (5 microM) decreased, an increas...