AMD3100 (Plerixafor), a specific antagonist of CXCR4, is the most potent small molecule non-peptide inhibitor to CXCR4/CXCL12 axis. The chemokine receptor CXCR4 and its ligand CXCL12 (SDF-1) expressed in variety tumor cells play an important role regulating biological behavior. microenvironment (TME) environment around tumor, comprising blood vessels, immune cells, fibroblasts, signaling molecu...

Akciğer kanseri, dünya çapında hem erkeklerde de kadınlarda kansere bağlı önde gelen ölüm nedenlerindendir. SLIT2/ROBO1 sinyali, çeşitli kanser tiplerini inhibe ettiği bildirilen çok önemli bir yolaktır. CXCR4, ilerlemesinde rol oynayan kemokin reseptörüdür. Silimarin, başta karaciğer hastalıkları olmak üzere akciğer kanseri dahil kanserlerde anti-kanserojen aktivitesi öne sürülen fitokimyasald...

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

background: metastasis is one the most leading cause of death from cancer. the chemokine receptor of cxcr4 has an important role in cell migration and cancer metastasis. additionally, metastasis is always associated with the process of epithelial-mesenchymal transition (emt). in this study the correlation between expression of cxcr4 and emt-tfs has been examined. methods: the expression of cxcr...

Abstract Placental dysfunction originates during placental development, specifically the events of placentation. Vascularization is a key component placentation due to its role in fetal-maternal exchange. Cytokines are regulators development; signaling chemokine ligand 12 (CXCL12) and receptor (CXCR4) drives vascularization. Utilizing an vivo sheep model, we demonstrated that suppressing CXCL12...

Ultraviolet B (UVB) triggers lupus flare by worsening skin lesions and systemic symptoms, i.e. nephritis. We have reported that UVB exposure induces inflammation with neutrophil infiltration extracellular trap (NET) formation in mice. also found induced proteinuria young female lupus-prone The relevant mechanisms regarding dermal-renal crosstalk is unclear. examined lesions, proteinuria, of neu...