نتایج جستجو برای: کموکاین cxcl12 sdf

تعداد نتایج: 5690  

Journal: :Cancer research 2005
Jean-Marc Navenot Zixuan Wang Michael Chopin Nobutaka Fujii Stephen C Peiper

The product of the KiSS-1 gene is absent or expressed at low level in metastatic melanoma and breast cancer compared with their nonmetastatic counterparts. A polypeptide derived from the KiSS-1 product, designated kisspeptin-10 (Kp-10), activates a receptor coupled to Galphaq subunits (GPR54 or KiSS-1R). To study the mechanism by which Kp-10 antagonizes metastatic spread, the effect on CXCR4-me...

Journal: :Cell 2008
Bijan Boldajipour Harsha Mahabaleshwar Elena Kardash Michal Reichman-Fried Heiko Blaser Sofia Minina Duncan Wilson Qiling Xu Erez Raz

Primordial germ cell (PGC) migration in zebrafish is directed by the chemokine SDF-1a that activates its receptor CXCR4b. Little is known about the molecular mechanisms controlling the distribution of this chemoattractant in vivo. We demonstrate that the activity of a second SDF-1/CXCL12 receptor, CXCR7, is crucial for proper migration of PGCs toward their targets. We show that CXCR7 functions ...

Journal: :Circulation journal : official journal of the Japanese Circulation Society 2011
Paloma Gil-Bernabe Daniel Boveda-Ruiz Corina D'Alessandro-Gabazza Masaaki Toda Yasushi Miyake Rumi Mifuji-Moroka Motoh Iwasa John Morser Esteban C Gabazza Yoshiyuki Takei

BACKGROUND A moderate intake of alcohol is associated with lower cardiovascular mortality, and the role of circulating progenitor cells in the beneficial effect of alcohol on atherosclerosis is unclear. The hypothesis of this study was that alcohol ameliorates atherosclerosis by modulating the circulating levels of stromal cell-derived growth factor (SDF)-1 and vascular progenitor cells. METH...

Journal: :International journal of molecular medicine 2007
Jan Dimberg Anders Hugander Sture Löfgren Dick Wågsäter

The chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1), is a small protein that regulates leukocyte trafficking and is variably expressed in a number of normal and cancer tissues. CXCL12 as ligand and its receptor CXCR4 have been implicated in colorectal cancer (CRC) progression including angiogenesis and metastasis. A CXCL12 gene variant CXCL12-A (CXCL12-G801A, a single nucl...

Journal: :Clinical and experimental rheumatology 2005
S K Singh H Morbach T Nanki H J Girschick

OBJECTIVE Lyme borreliosis is characterized by strong inflammatory reactions probably due to the presence of Borrelia burgdorferi in the joint. It has been suggested that Borrelia induces the immunological mechanisms that either can amplify the inflammatory response or can suppress it. To reveal the underlying mechanisms of chemoattraction and activation of responding leukocytes, we investigate...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Beverly A Teicher Simon P Fricker

Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathwa...

2017
Meng Wang Tie Lin Yicun Wang Song Gao Zhaoyang Yang Xuan Hong Gongyan Chen

AIMS Poor efficacy of chemotherapy drugs in non-small-cell lung cancer (NSCLC) is the key reason for the failure of treatment, but the mechanism of this remains largely unknown. Stromal cell-derived factor 1-alpha (SDF-1α/CXCL12) is a small chemotactic cytokine protein that plays an important role in tumor progression. In this study, we investigated the anti-apoptotic mechanism of the CXCL12/CX...

Journal: :Cancer research 2005
Ilona Kryczek Andrzej Lange Peter Mottram Xavier Alvarez Pui Cheng Melina Hogan Lieve Moons Shuang Wei Linhua Zou Véronique Machelon Dominique Emilie Margarita Terrassa Andrew Lackner Tyler J Curiel Peter Carmeliet Weiping Zou

Ovarian carcinomas have a poor prognosis, often associated with multifocal i.p. dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites and tumors of patients with untreated ovarian carcinoma. We observed that malignant ascites fluid induced potent in vivo neovascularization in Matrigel assay. We detected...

2011
Jason A. Wojcechowskyj Jessica Y. Lee Steven H. Seeholzer Robert W. Doms

CXCL12 (SDF-1) is a chemokine that binds to and signals through the seven transmembrane receptor CXCR4. The CXCL12/CXCR4 signaling axis has been implicated in both cancer metastases and human immunodeficiency virus type 1 (HIV-1) infection and a more complete understanding of CXCL12/CXCR4 signaling pathways may support efforts to develop therapeutics for these diseases. Mass spectrometry-based ...

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