background: the airway surfaces are one of the most common ways of entry of infectious agents. oral cavity associated lymphoid tissues are inductive site of humoral immune responses in inflammatory and infectious disorders of the upper respiratory tract. these lymphoid tissues play important roles in the induction of salivary iga. the impact of upper respiratory tract diseases on salivary iga p...

background: in this study we have prepared the iga solution from normal human plasma using plasma fractionation and ion exchange chromatography. materials and methods: using fractionation of plasma with cold ethanol (starting with 8% ethanol), fraction iii was prepared as a suitable source for iga preparation. then it was treated with caprylic acid for separation of impurities. for enrichment o...

selective deficiency of immunoglobulin a (iga) is the most frequent primary hypogammaglobulinemia. as some iga-deficient patients have iga antibodies in their plasma which may cause anaphylactic reactions, blood centers usually maintain a list of iga-deficient blood donors to prepare compatible blood components. in this study we determined the incidence of selective iga deficiency (sigad) in no...

Background/aim: In this study, we aimed to investigate different types of celiac antibodies in psoriasis patients and see if the presence was associated with other variables. Materials methods: We included plaque who were followed up our dermatology clinic between February 2019 2021 added a healthy control group for comparison. The studied serum antitissue transglutaminase (tTG)-IgA, tTG-IgG, a...

background: iga nephropathy, a prevalent disease in asia, is considered the main cause of end stage renal disease among primary glomerular disease. objective: to determine the frequency of different clinical, histopathological and immunofluorescent characteristics of iga nephropathy. methods: renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. b...

Passive hemagglutination assays (PHA) may be used to detect IgA antibodies to confirm clinical diagnoses of suspected IgA anaphylactic transfusion reactions. Passive hemagglutination inhibition assays (PHIA) may be used to identify IgA-deficient blood donors whose plasma-containing components are transfused to prevent anaphylactic transfusion reactions in prospective recipients at risk because ...

Background: The study of antiphospholipid antibodies (aPL), not included in the Sydney diagnostic criteria, syndrome (APS) and systemic lupus erythematosus (SLE) is poorly understood. Objectives: To determine frequency detection IgA-aCL IgA-aβ2GP1 IgG to β2GP1 domain 1 (IgG-aβ2GP1-D1) patients with APS without SLE. Methods: ELISA chemiluminescence assays (CMA) were used test 63 sera patients: 2...

Immunoglobulin A (IgA) is the primary immune response induced in the intestine by rotavirus infection, but vaccination with virus-like particles induces predominantly IgG, not IgA. To definitively assess the role of IgA in protection from rotavirus infection, IgA knockout mice, which are devoid of serum and secretory IgA, were infected and then rechallenged with murine rotavirus at either 6 wee...