The development of multidrug-resistance (MDR) is a major contributor to death in colorectal carcinoma (CRC). Here, we investigated the possible role of microRNA (miR)-503-5p in drug resistant CRC cells. Unbiased microRNA array screening revealed that miR-503-5p is up-regulated in two oxaliplatin (OXA)-resistant CRC cell lines. Overexpression of miR-503-5p conferred resistance to OXA-induced apo...

Gene L Bowman1† & Joseph F Quinn2 †Author for correspondence 1Oregon Health & Science University, CR-131 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: [email protected] 2Oregon Health & Science University, Clinical Core, NIA-Layton Aging & Alzheimer’s Disease Center, OR, USA Tel.: +1 503 494 6976; Fax: +1 503 494 7499; Email: qu...

MicroRNAs (miRs) have been demonstrated to play key roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-503 in HCC has not been fully uncovered. In this study, we found that miR-503 was significantly downregulated in HCC tissues compared to nontumorous liver tissues. Moreover, lower miR-503 levels were associated with the malignan...

Epithelial-to-mesenchymal transition (EMT) is believed to be associated with cancer cell malignancy, and also to cause cancer invasion and metastasis. Recent evidence indicates that small non-protein coding RNA [microRNAs (miRNAs/miRs)] may act as powerful regulators of EMT. The present study aimed to systematically delineate miR-503 expression in gastric cancer and analyse the function of miR-...

Loss of pancreatic β cells is involved in pathogenesis of gestational diabetes mellitus (GDM). Recently, several studies have elucidated the connection between microRNAs (miRNAs) and diabetes mellitus (DM), but the role of miRNAs in GDM remains unclear. The aim of this study was to evaluate the potential functions of miRNAs in GDM and to investigate the underlying mechanisms of action. First, w...

Cytochrome c oxidase transfers electrons and protons for dioxygen reduction coupled with proton pumping. These electron and proton transfers are tightly coupled with each other for the effective energy transduction by various unknown mechanisms. Here, we report a coupling mechanism by a histidine (His-503) at the entrance of a proton transfer pathway to the dioxygen reduction site (D-pathway) o...

Deregulated microRNAs and their roles in tumorigenesis have attracted much attention in recent years. Although miR-503 was shown to be important in tumorigenesis, its role in osteosarcoma remains unknown. In this study, we focused on the expression and mechanisms of miR-503 in osteosarcoma development. We found that miR-503 was down-regulated in osteosarcoma cell lines and primary tumor samples...

The communication between vascular endothelial cells (ECs) and pericytes in the microvasculature is fundamental for vascular growth and homeostasis; however, these processes are disrupted by diabetes. Here we show that modulation of p75(NTR) expression in ECs exposed to high glucose activates transcription of miR-503, which negatively affects pericyte function. p75(NTR) activates NF-κB to bind ...

ةــصلاخلا : ُـي ةيساسلأا تاضارتفلاا نم ةلاحلا دادتملا يسدنهلا عيزوتلا ربتع ةراشلأل فوآرام ةجذمن ءادأ نم د ُّ حت يتلا ةيتوص لا . ة يعباتتلا ءاز جلأا جذو منأ نإ ف ،مو معلا ى لعو – تا يئزج كلذ آو ،ةيئاوش علا HMM ى لعو ، يف ةبوعص ةجرد يف ةدا يز ى لإ هرود ب يدؤ ي اً يئزج صقن لا اذ ه زواجتل ،صوصخلا روطلا د يدحتو بيرد ت . جذو من نمض توصلا تايئاصحلال يجيرد تلا ي نمزلا ر يغتلا جرد ن م ل ،ضار تفلاا اذ ه ى ل...

همدقم : ي رييغت يديئوريت ياهنومروه نازيم نيفرم هب هتسباو دارفا رد هتفا تـسا هدـش شرازـگ ديئوريت و زيفوپيه سوملااتوپيه روحم تيلاعف صوصخ رد يتوافتم جياتن و . رد غت هعلاطم نيا يي لاعف تار ي ت هدغ ت ي ئور ي ول نمزم و داح زيوجت اب د تفرگ رارق يسررب دروم نيفرم عطق مئلاع رب نيسكوريتو . شور اه : 42 رد غلاب رن يهاگشيامزآ ديفس شوم 6 دش هدافتسا هورگ . نيسكوريتوول هدننك تفايرد ياههورگ يقافص لخاد mg/...