Concentrations of total glycosylated haemoglobins (Hb A1) were measured in 40 diabetics at diagnosis and at monthly intervals after treatment with chlorpropamide, insulin, or diet alone was begun. The mean Hb A1 concentration at presentation in 16 patients treated with chlorpropamide was significantly higher than that in 12 patients treated with insulin, and the duration of glycaemic symptoms w...

disease includes the following observations, but their significance is not yet clear: (1) There is evidence of a connection between abnormal glucose tolerance and post' encephalitic Parkinson's disease (Gillhespy and Paton, i960; Terrana and Adragn^ 1951). McCowan, Harris and Mann (1926) give glucose tolerance curves for a group of patients with post-encephalitic Parkinsonism which are clearly ...

Many non-insulin dependent diabetics (NIDDs) on the sulphonylurea chlorpropamide experience intense facial flushing after taking alcohol even in small amounts. This chlorpropamide alcohol flush (CPAF) was first recognized within months of the introduction of the drug in the 1950s [ l ] but, although an alcohol flush occasionally occurs with tolbutamide [ 2 , 31, it has not been reported with ot...

The antidiabetic effect of chloroform – methanol extract of Abrus precatorious seed, was studied in alloxan diabetic rabbits. The effect was compared to that of chlorpropamide – a known antidiabetic drug in the class of sulphonylurea and a control group that received normal saline instead of the extract. Normal blood glucose levels drawn before the alloxan injection were 127.80 ± 2.55, 114.30 ±...