Introduction. The development of new approaches to screening colorectal cancer (CRC), including those based on such molecular genetic methods as the assessment microRNA(miRNA) expression, is an urgent clinical task. Purpose study. study was aimed at a model for CRC prediction miRNA-21 expression level in saliva and plasma. Materials Methods. levels plasma (P-miRNA-21) saliva(S-miRNA-21) samples...

Glioblastoma multiform(GBM) is the most prevalent primary brain tumor. Exosomes are extracellular vehicles for exchanging information between various cell types including cancer and normal cells. Exosomes are indicative of pathophysiological conditions of brain tumors that could be used in diagnosis and prognosis of GBM. In tumors, exosomes could carry various molecules like several miRNAs and ...

Objective(s): Menopause and diabetes obviously increase the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of miRNA-29, miRNA-133, IGF-1 and Bcl-2 genes and Bcl-2 protein and caspase 3 activity in the hearts of female rats. Materials and Methods: Forty Female Wistar rats were ...

the importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. by taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. they have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. micrornas (mirnas) are o...

فرزند‌پروری پس از طلاق یکی تکالیف حساس پیش روی والدین مُطلقه، و عوامل مؤثر در سلامت روانی فرزندان به شمار می‌آید. هدف این مطالعه کشف تبیین تجارب زیسته‌ هم‌والدگری است. روش کیفی با استفاده پدیدارشناسی توصیفی انجام شد. جامعه پژوهش شامل کلیه‌ والدینی بود که تجربه‌ فرزندپروری را داشته‌اند. برای تعیین حجم نمونه معیار اشباع داده شد نمونه‌گیری هدفمند تعداد 12 نفر (زن، مرد) انتخاب شدند مورد مصاحبه‌ نیمه...

single-nucleotide polymorphisms (snps) in mirnasmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. our study aimed to evaluate the possible association between mirna-146a rs2910164 and mirna-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (ptb) in a sample of iranian population. this case- control study was perfor...

Abstract Background Autism spectrum disorder is a condition related to brain development that affects person’s perception and socialization, resulting in problems social interaction communication. It has no single known cause, yet several different genes appear be involved autism. As genetically complex disease, dysregulation of miRNA expression miRNA–mRNA interactions might feature autism diso...