Cleft palate is a common birth defect caused by disruptions in secondary palate development. Anterior-posterior (A-P) regional specification plays a critical role in palate development and fusion. Previous studies have shown that at the molecular level, the anterior palate can be defined by the expression of Shox-2 and the posterior palate by Meox-2 expression in certain mouse strains. Here, we...

Cleft palate, the most frequent congenital craniofacial birth defect, is a multifactorial condition induced by the interaction of genetic and environmental factors. In addition to complete cleft palate, a large number of human cases involve soft palate cleft and submucosal cleft palate. However, the etiology of these forms of cleft palate has not been well understood. T-box transcriptional fact...

Clefting of the secondary palate is one of the most common human birth defects and results from failure of the palatal shelves to fuse during embryonic development. Palatogenesis is traditionally considered to be a highly conserved developmental process among mammalian species. However, cleft palate phenotypes in humans are considerably more variable than those seen in mice, the most common ani...

objectives: one of the factors predicting language impairments is an early limited lexicon in children. an early limited lexicon can also lead to limited performances in other language areas. this study was aimed to examine receptive and expressive vocabulary in 8-16 month-old children with cleft lip and palate as a predictor of development in other language areas. materials: the macarthur-bate...

To determine if Wnt5a gene involved in orofacial development, especially secondary palate development, we checked Wnt5a protein and mRNA in wild-type mouse embryos, and also searched Wnt5a knockout mice palates. We found Wnt5a is expressed during orofacial development, especially necessary for normal secondary palate and tongue morphogenesis. Wnt5a deficient mice exhibit cleft palate and abnorm...

Pleomorphic adenoma is the most prevalent salivary tumor, 65% of which occur in major glands. This tumor varies in terms of size depending on the gland where it is located. The most common sites of the minor salivary glands are the palate, lips, cheeks, and throat. Palatal pleomorphic adenoma is laterally located, rarely crossing the midline. This tumor is painless with slow growth rate, which ...

This paper presents a method for imaging the palate and extracting the palate contour from ultrasound images. Ultrasound does not usually capture the palate because the air at the tongue surface reflects the ultrasound beam back to the transducer. However, when the tongue touches the palate during a swallow, the ultrasound beam is transmitted through the soft tissue until it reaches and is refl...

Children born with a cleft lip and or palate face numerous difficulties during the course of their lives. Their families must respond to the challenge of a high level of burden of care required by these patients. The studies listed in this thesis benchmark the characteristics of cleft lip and palate in a cohort of patients living in Northern Finland. These studies strived to consider epidemiolo...