Protein Z (PZ) is a 62 kDa vitamin K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). ZPI is a recently identified 72 kDa member of the serpin superfamily of proteinase inhibitors that contains a tyrosine at its reactive center. PZ circulates in plasma in a complex with ZPI. Inhibition of factor Xa by ZPI in the ...

As a regulator of coagulation, abnormal Protein Z (PZ) expression may lead to the formation of blood clots in humans. While previous studies have shown that PZ protein is altered in several types of cancer, however, additional observations are needed to understand the complex biology involved. Herein, we investigated local alterations in PZ expression in lung adenocarcinomas by measuring gene a...

We investigated the solution structure and dynamics of the human anti-coagulation protein Z (PZ) in the complex with protein Zdependent protease inhibitor (ZPI) to order to understand key structural changes in the presence and absence of Ca(2+). Structural features of the complete complex of PZ-ZPI are poorly understood due to lack of complete atomic model of the PZ-ZPI complex. We have constru...

The fluorescence spectrum of aqueous phenazine (PZ), an N-heterocyclic compound, shows some interesting features that indicate the formation of PZ-water complex in the excited state. Two types of complexes are postulated; Type I, formed by the association of water molecule with one of the nitrogen of PZ and Type II, formed by the association of water molecules with both the nitrogen of PZ. In a...

ed actuation: Inflation by force in normal direction Actuation location: applied to membrane Actuation type: PZ (force in local z-direction) Support condition: 1 x Fixed support (YP = PX + PZ) 1 x Pinned support (PP = PX + PY + PZ)

We consider the families of finite Abelian groups Z/pZ × Z/pZ, Z/pZ and Z/pZ×Z/qZ for p, q two distinct prime numbers. For the two first families we give a simple characterization of all functions whose support has cardinality k while the size of the spectrum satisfies a minimality condition. We do it for a large number of values of k in the third case. Such equality cases were previously known...

Metalation of 3-phenyl-5-(2-pyridyl)pyrazole (HPz, 1) with alkyllithium and -zinc compounds in tetrahydrofuran (thf) yields dinuclear products [(thf)Li(Pz)]2 (2) and [MeZn(Pz)]2 (3), respectively. Magnesiation of 1 with diethylmagnesium in tetrahydrofuran in the presence of 1,4-dioxane leads to cocrystallization of mononuclear [(thf)2Mg(Pz)2] (4a) and [(diox)2Mg(Pz)2] (4b). Metalation of 1 with...