نتایج جستجو برای: ژن stk15

تعداد نتایج: 15850  

Journal: :Biochemical and biophysical research communications 2008
Jian Du Sandra Jablonski Tim J Yen Gregory J Hannon

Alterations in the expression and activity of the centrosomal kinase, Aurora-A/STK15, affect genomic stability, disrupt the fidelity of centrosome duplication, and induce cellular transformation. A mitotic spindle-associated protein, astrin/DEEPEST, was identified as an Aurora-A interacting protein by a two-hybrid screen. Astrin and Aurora-A co-express at mitosis and co-localize to mitotic spin...

Journal: :Cancer research 2005
Tatsuo Hata Toru Furukawa Makoto Sunamura Shinichi Egawa Fuyuhiko Motoi Noriyuki Ohmura Tomotoshi Marumoto Hideyuki Saya Akira Horii

AURKA/STK15/BTAK, the gene encoding Aurora A kinase that is involved in the regulation of centrosomes and segregation of chromosomes, is frequently amplified and overexpressed in various kinds of human cancers, including pancreatic cancer. To address its possibility as a therapeutic target for pancreatic cancer, we employed the RNA interference technique to knockdown AURKA expression and analyz...

Journal: :Journal of clinical pathology 2009
D Llobet J Pallares A Yeramian M Santacana N Eritja A Velasco X Dolcet X Matias-Guiu

This article reviews the main molecular alterations involved in endometrial carcinoma. Five molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and beta-catenin genes) are characteristic of endometrioid carcinomas, whereas non-endometrioid carcinomas show alterations of p53, loss of heterozygosity (LOH) on several chromosomes, as well as other molecular alte...

Journal: :Molecular cancer research : MCR 2003
Leslie C Hodges Jennifer D Cook Edward K Lobenhofer Leping Li Lee Bennett Pierre R Bushel C Marcelo Aldaz Cynthia A Afshari Cheryl Lyn Walker

Tamoxifen is a widely used breast cancer therapeutic and preventative agent. Although functioning as an estrogen antagonist at the cellular level, transcriptional profiling revealed that at the molecular level, tamoxifen functions largely as an agonist, virtually recapitulating the gene expression profile induced in breast cancer cells by estrogen. Remarkably, tamoxifen induces transcription fa...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید