نتایج جستجو برای: ژن ship2

تعداد نتایج: 15922  

2016
Qian Yang Yiqiong Ma Yipeng Liu Wei Liang Xinghua Chen Zhilong Ren Huiming Wang Pravin C. Singhal Guohua Ding Carl-Henrik Heldin

Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine kinase that is involved in cell survival and regulation of the cytoskeleton. Phosphorylated nephr...

Journal: :The FASEB Journal 2021

The Src homology 2 containing inositol 5-phosphatase (SHIP2) is a large multidomain enzyme that catalyzes the dephosphorylation of phospholipid phosphatidylinositol 3,4,5-triphosphate (PI(3,4,5)P3) to form PI(3,4)P2. PI(3,4,5)P3 key lipid second messenger controlling recruitment signaling proteins plasma membrane, thereby regulating plethora cellular events, including proliferation, growth, apo...

Journal: :Endocrinology 2008
Syota Kagawa Yoshiyuki Soeda Hajime Ishihara Takeshi Oya Masakiyo Sasahara Saori Yaguchi Ryo Oshita Tsutomu Wada Hiroshi Tsuneki Toshiyasu Sasaoka

SH2-containing inositol 5'-phosphatase 2 (SHIP2) is a 5'-lipid phosphatase hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI(3,4,5)P(3) to PI(3,4)P(2) in the regulation of insulin signaling, and is shown to be increased in peripheral tissues of diabetic C57BL/KSJ-db/db mice. To clarify the impact of SHIP2 in the pathogenesis of insulin resistance with type 2 diabetes, we generated t...

Journal: :Oncology reports 2007
Shuji Sumie Takumi Kawaguchi Mina Komuta Ryoko Kuromatsu Satoshi Itano Koji Okuda Eitaro Taniguchi Eiji Ando Akio Takata Nobuyoshi Fukushima Hironori Koga Takuji Torimura Masamichi Kojiro Michio Sata

Glucose intolerance frequently is found in hepatocellular carcinoma (HCC) patients with hepatitis C virus (HCV) infection; however, the significance of glucose intolerance remains unclear. In addition, SH2 domain-containing inositol phosphatase (SHIP) 2 is a negative regulator of intracellular insulin signaling; however, changes in SHIP2 expression have not been investigated in HCC. To assess t...

مشکانی, رضا, گرگانی فیروزجایی, ستار,

Introduction: Dyslypydmy is one of the risk factors of cardiovascular disease in diabetics. Dyslypydmy is diagnosed by increasing in plasma triglyceride density, decreasing HDL Cholesterol, and increasing LDL especially small LDL. Several evidences from human and animal studies indicate that the role of insulin resistance is a major cause of hypertrigly ceridemia in diabetics and people with me...

Journal: :American journal of physiology. Endocrinology and metabolism 2003
Daniela F Bertelli Miriam Ueno Maria E C Amaral Marcos Hikari Toyama Everardo M Carneiro Sergio Marangoni Carla R O Carvalho Mario J A Saad Licio A Velloso A Carlos Boschero

Short-term muscle denervation is a reproducible model of tissue-specific insulin resistance. To investigate the molecular basis of insulin resistance in denervated muscle, the downstream signaling molecules of the insulin-signaling pathway were examined in intact and denervated soleus muscle of rats. Short-term denervation induced a significant fall in glucose clearance rates (62% of control, P...

2014
Germaine D. Agollah Manuel L. Gonzalez-Garay John C. Rasmussen I-Chih Tan Melissa B. Aldrich Chinmay Darne Caroline E. Fife Renie Guilliod Erik A. Maus Philip D. King Eva M. Sevick-Muraca

The lymphatic vasculature plays a critical role in a number of disease conditions of increasing prevalence, such as autoimmune disorders, obesity, blood vascular diseases, and cancer metastases. Yet, unlike the blood vasculature, the tools available to interrogate the molecular basis of lymphatic dysfunction/disease have been lacking. More recently, investigators have reported that dysregulatio...

2005
Karim Benkirane Farhad Amiri Quy N. Diep Mohammed El Mabrouk Ernesto L. Schiffrin

Benkirane, Karim, Farhad Amiri, Quy N. Diep, Mohammed El Mabrouk, and Ernesto L. Schiffrin. PPARinhibits ANG IIinduced cell growth via SHIP2 and 4E-BP1. Am J Physiol Heart Circ Physiol 290: H390–H397, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00662.2005.—The present study evaluated the effects of peroxisome proliferator-activated receptor (PPAR)activators on ANG II-induced s...

Journal: :The Journal of Cell Biology 2007
Kazuhiro Aoki Takeshi Nakamura Takanari Inoue Tobias Meyer Michiyuki Matsuda

The local accumulation of phosphatidylinositol (3,4,5) trisphosphate (PIP(3)) and resulting activation of Rac1/Cdc42 play a critical role in nerve growth factor (NGF)-induced neurite outgrowth. To further explore the mechanism, we visualized PIP(3), phosphatidylinositol (3,4) bisphosphate, and Rac1/Cdc42 activities by fluorescence resonance energy transfer (FRET) imaging in NGF-stimulated PC12 ...

2017
Miki Fukumoto Takeshi Ijuin Tadaomi Takenawa

Phosphoinositides play pivotal roles in the regulation of cancer cell phenotypes. Among them, phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2 ) localizes to the invadopodia, and positively regulates tumor cell invasion. In this study, we examined the effect of PI(3,4)P2 on focal adhesion dynamics in MDA-MB-231 basal breast cancer cells. Knockdown of SHIP2, a phosphatidylinositol 3,4,5-trisphos...

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