نتایج جستجو برای: ژن loc387715
تعداد نتایج: 15841 فیلتر نتایج به سال:
10.2217/14750708.4.2.167 © 2 Evaluation of: Yang Z, Camp NJ, Sun H et al.: A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science 314(5801), 992–993 (2006) [1]. Age-related macular degeneration is a common cause of visual loss in the elderly, yet the genetic basis for this disease is poorly understood. Linkage studies show a major susceptibility locus ...
PURPOSE To present genome-wide association analyses of genotypic and environmental risks on age-related macular degeneration (AMD) using 593 subjects from the age-related eye disease study (AREDS), after adjusting for population stratification and including questionable controls. METHODS Single nucleotide polymorphism (SNP) associations with AMD for the non-Hispanic white population were inve...
Molecular genetic studies of age-related maculopathy (ARM), including family-based linkage studies and case-control association studies, have yielded valuable insights into the risks of developing this condition and potential disease-causing mechanisms. Variants in the complement factor H gene and LOC387715 have consistently been shown to be major risk factors for ARM. Additional genes, and env...
A recent study demonstrated that a particular genetic susceptibility (LOC387715), combined with smoking, confers a significantly higher risk of AMD than either factor alone (Schmidt et al 2006). This is consistent with reports from family aggregation studies, which suggest that a first-degree relative of an individual with AMD is five times more likely to develop AMD than a family member of som...
Major genetic factors for age-related macular degeneration (AMD) have recently been identified as susceptibility risk factors, including variants in the CFH gene and the ARMS2 LOC387715/HTRA1locus. Our purpose was to perform a case-control study in two populations among individuals who did not carry risk variants for CFHY402H and LOC387715 A69S (ARMS2), called "study" individuals, in order to i...
PURPOSE To evaluate the frequency of 12 single nucleotide polymorphisms (SNPs) of complement factor H (CFH) and LOC387715/ARMS2/HRTA1 and their association with some of the presenting clinical features of neovascular age-related macular degeneration (AMD). METHODS In this prospective non-comparative case series forty four naïve patients with neovascular AMD were genotyped using sequencing or ...
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