نتایج جستجو برای: ژن itga4

تعداد نتایج: 15834  

Journal: : 2023

هدف: از چالش­های عمده بشریت افزایش افسردگی و اختلال عملکرد جنسی ناشی داروهای ضدافسردگی است. با توجه به نقش سلول­های سرتولی در اسپرماتوژنز، پژوهش حاضر، اثر داروی دولوکستین را بر زنده­مانی، آپوپتوزیس بیان ژن­های Bax و­ (Connexin 43) Cx43 بررسی کرده مواد روش‌‌ها: TM4 محیط DMEM/F12 حاوی %5/2 FBS، 5% سرم اسب %1 پنی سیلین-استرپتومایسین کشت شدند. دوزهای 30،60، 15، 5/7، 75/3 میکرو­گرم/ میلی­لیتر زمان­ه...

Journal: :Twin research and human genetics : the official journal of the International Society for Twin Studies 2017
Bochao D Lin Gonneke Willemsen Iryna O Fedko Rick Jansen Brenda Penninx E de Geus C Kluft JoukeJan Hottenga Dorret I Boomsma

The monocyte-lymphocyte ratio (MLR) is a useful biomarker for disease development, but little is known about the extent to which genetic and environmental factors influence MLR variation. Here, we study the genetic architecture of MLR and determine the influence of demographic and lifestyle factors on MLR in data from a Dutch non-patient twin-family population. Data were obtained in 9,501 indiv...

Journal: :Biomedicines 2023

The aim of this study was to perform a genome-wide expression analysis whole-blood samples from people with optic neuritis (ON) and determine differentially expressed mRNAs compared healthy control subjects. included eight acute ON six Gene analyzed using DNA microarrays for whole-human-genome analysis, which contain 54,675 25-base pairs. additional biostatistical gene ontology set enrichment (...

Journal: :Reproductive Health 2021

Abstract Background Spermatogonial stem cells (SSCs) in the testis are crucial for transferring genetic information to next generation. Successful transplantation of SSCs infertile men is an advanced therapeutic application reproductive biology research. Methods In this experimental research, both vitro and vivo characterization undifferentiated differentiated were performed by morphology—immun...

Journal: :Journal of Clinical Periodontology 2021

Aim Our aim was to evaluate gene expression profiling of fibroblasts from human alveolar mucosa (M), buccal attached gingiva (G) and palatal (P) tissues during early wound healing, correlating it with clinical response. Materials Methods M, G P biopsies were harvested six patients at baseline 24 hr after surgery. Clinical response evaluated through Early Healing Score (EHS). Fibrotic markers au...

Journal: :Journal of Immunology 2023

Abstract Innate lymphoid cells (ILCs) are largely tissue-resident and do not express clonotypic receptors. In humans, ILCs primarily described within the mucosal tissues. However, their development functions in human draining lymph nodes (LN) bone marrow (BM) unknown. Here, we performed single-cell RNA sequencing to unravel tissue-specific transcriptional profiles of 47,287 abdominal thoracic L...

Journal: :Blood 2007
Pradeep Sathyanarayana Madhu P Menon Olga Bogacheva Oleg Bogachev Knut Niss William S Kapelle Estelle Houde Jing Fang Don M Wojchowski

Epo's erythropoietic capacity is ascribed largely to its antiapoptotic actions. In part via gene profiling of bone marrow erythroblasts, Epo is now shown to selectively down-modulate the adhesion/migration factors chemokine receptor-4 (Cxcr4) and integrin alpha-4 (Itga4) and to up-modulate growth differentiation factor-3 (Gdf3), oncostatin-M (OncoM), and podocalyxin like-1 (PODXL). For PODXL, E...

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