نتایج جستجو برای: ژن catsper

تعداد نتایج: 15936  

2018
Hamideh Ghanbari Sara Keshtgar Marjaneh Kazeroni

Background Low levels of reactive oxygen species (ROS) and calcium are necessary for sperm function. NADPH oxidase 5 (NOX5) is a membrane enzyme which produces ROS. This enzyme is dependent on calcium for its activity. We investigated the importance of NOX5 and an important calcium channel (CatSper) on sperm function. Methods This laboratory in-vitro study was done in Shiraz, Iran, 2016. Norm...

2017
Jean-Ju Chung Kiyoshi Miki Doory Kim Sang-Hee Shim Huanan F Shi Jae Yeon Hwang Xinjiang Cai Yusuf Iseri Xiaowei Zhuang David E Clapham

We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm ...

Journal: :Pharmacological reviews 2005
David E Clapham David L Garbers

CatSper channels (CatSper1–4) are named after the first putative cation channel of sperm (Quill et al., 2001; Ren et al., 2001). CatSpers are putative six-transmembrane (6TM) voltage-gated Ca -permeant channels and seem to be specific to sperm cells. CatSper1 and 2 are each essential for the hyperactivation of sperm cell motility, which is required for fertility. Sequence identities among these...

2012
Linda Lefièvre Katherine Nash Steven Mansell Sarah Costello Emma Punt Joao Correia Jennifer Morris Jackson Kirkman-Brown Stuart M. Wilson Christopher L. R. Barratt Stephen Publicover

Ca2+i signalling is pivotal to sperm function. Progesterone, the best-characterized agonist of human sperm Ca2+i signalling, stimulates a biphasic [Ca2+]i rise, comprising a transient and subsequent sustained phase. In accordance with recent reports that progesterone directly activates CatSper, the [Ca2+]i transient was detectable in the anterior flagellum (where CatSper is expressed) 1-2 s bef...

2017
Sean G. Brown Sarah Costello Mark C. Kelly Mythili Ramalingam Ellen Drew Stephen J. Publicover Christopher L.R. Barratt Sarah Martins Da Silva

STUDY QUESTION Does progesterone in human follicular fluid (hFF) activate CatSper and do other components of hFF modulate this effect and/or contribute separately to hFF-induced Ca2+ signaling? SUMMARY ANSWER hFF potently stimulates CatSper and increases [Ca2+]i, primarily due to high concentrations of progesterone, however, other components of hFF also contribute to [Ca2+]i signaling, includ...

2014
Mahsa Askari Jahromi Mansoureh Movahedin Zohreh Mazaheri Masoud Amanlu Seyed Javad Mowla Hosein Batooli

BACKGROUND Catsper proteins are responsible for entering Ca(2+) to the cell and play an important role in sperm motility and male fertility. Antioxidants are vital for sperm motility too. Escanbil (Calligonum) extract possess some of the important antioxidant like Catechin and Quercetin. OBJECTIVE Here we investigated the effects of Escanbil (Calligonum) extract on the sperm parameters and th...

Journal: :cell journal 0

objective: catsper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. catsper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility. in this study, we have explored targeting of the extracellular loop as an approach for the generation of antibodies with the potential ability to b...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Xu-Hui Zeng Chengtao Yang Xiao-Ming Xia Min Liu Christopher J Lingle

Following entry into the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that results in competence to fertilize ova. Associated with capacitation is an increase in membrane conductance to both Ca(2+) and K(+), leading to an elevation in cytosolic Ca(2+) critical for activation of hyperactivated swimming motility. In mice, the Ca(2+) conductance (alka...

Journal: :The FASEB Journal 2021

Sperm acquire the ability to fertilize in a process called capacitation and undergo hyperactivation, change motility pattern, which depends on Ca2+ transport by CatSper channels. is essential for fertilization it subjected complex regulation that not fully understood. Here, we report similar CatSper, Cdc42 distribution principal piece confined four linear domains this localization disrupted Cat...

Journal: :international journal of reproductive biomedicine 0
shabnam mohammadi mehdi jalali mohammad reza nikravesh alireza fazel alireza ebrahimzadeh mehran gholamin

background: catsper genes are a novel family of four sperm-specific calcium channels, which indicate testis-specific expression patterns. despite the crucial role of catsper genes in the male reproduction, very little is known about the factors that regulate their expression. objective: the objective of this study was to investigate the effects of vitamin e treatment on the expression of catspe...

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