A new borohydride, [CH(3)NH(3)](+)[BH(4)](-), has been synthesized through the metathesis of CH(3)NH(3)F and NaBH(4) in methylamine. Room-temperature X-ray diffraction studies have shown that [CH(3)NH(3)](+)[BH(4)](-) adopts a tetragonal unit cell with considerable hydrogen mobility similar to that observed in NH(3)BH(3). The kinetics and thermodynamics of hydrogen release have been investigate...

Tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide synthases (NOS). This study investigated the effect of increasing BH(4) levels on hypoxia-induced pulmonary vasoconstriction (HPV). Sprague Dawley rats and hph-1 (BH(4) deficient) mice were given BH(4) before and during HPV in an isolated perfused lung preparation. BH(4) inhibited HPV in a concentration-dependent manner and i...

Increased oxidative stresses are implicated in the pathogenesis of Parkinson's disease, and dopaminergic neurons may be intrinsically susceptible to oxidative damage. However, the selective presence of tetrahydrobiopterin (BH(4)) makes dopaminergic neurons more resistant to oxidative stress caused by glutathione depletion. To further investigate the mechanisms of BH(4) protection, we examined t...

Background Glaucoma is a serious eye disease that can lead to loss of vision. Unfortunately, effective treatments are limited by poor bioavailability of antiglaucoma medicine due to short residence time on the preocular surface. Materials and methods To solve this, we successfully prepared novel controlled-release ion-exchange microparticles to deliver betaxolol hydrochloride (BH). Montmorill...

UNLABELLED Our aim was to compare the maximum standardized uptake value (SUVmax) between breath-hold (BH) PET/CT and free-breathing (FB) PET/CT. METHODS The features of phantom data were analyzed, after which a clinical study was performed. A total of 108 consecutive patients with lung cancer were examined using lutetium oxyorthosilicate (LSO)-based PET/CT. The patients were instructed to bre...

Based on evolutionary scenarios for binary stellar evolution we study the merging rates of relativistic binary stars (NS+NS, NS+BH, BH+BH) under di erent assumptions of BH formation. We nd the BH+BH merging rate in the range one per 200,000 { 500,000 year in a Milky-Way type galaxy, while the NS+NS merging rate Rns is approximately 10 times as high, which means that the expected event rate even...

OBJECTIVES : To provide descriptive information on behavioral health (BH) productivity and billing practices within a pediatric primary care setting. METHODS : This retrospective investigation reviewed 30 months of electronic medical records and financial data. RESULTS : The percent of BH provider time spent in direct patient care (productivity) was 35.28% overall, with a slightly higher quarte...