Background A rare missense APOE variant (L28P; APOE*4Pittsburgh) has been reported to be a risk factor for Alzheimer’s disease (AD). However, sinceL28P observed only among APOE*4 carriers, its independent genetic association is uncertain. In this study, we re-evaluated in large case-control sample of 15,762 U.S. Whites aged ≥60 years and investigated effect. Method Samples were derived from thr...

OBJECTIVE In mice that are heterozygous for mitochondrial superoxide dismutase (SOD2(+/-)) with apoE deficiency (apoE(-/-)), mitochondrial DNA damage increases formation of atherosclerotic lesions. The purpose of this study was to determine whether SOD2 provides protection against increased vascular superoxide and endothelial dysfunction in apoE-deficient mice. METHODS AND RESULTS Four groups...

Background Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and Apolipoprotein E (ApoE) are two of the strongest genetic risk factors for late-onset Alzheimer’s disease (AD), but while their interplay in microglial response to AD pathology is hotly studied, surprisingly little known about mechanism by which variants impair this role. Method To define structural AD-associated TREM2-ApoE ...

Background There is increasing interest in blood-based metabolic biomarkers for Alzheimer’s disease (AD). Studies show consistently that at branched chain amino acids (BCAAs) and a large scale of lipids are changed patients with AD. Little known how these metabolites associate to age, genes apolipoprotein E (APOE). This study aims over the lifespan determine influence sex APOE. Method We conduc...

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system, with a complex etiology that includes a strong genetic component. The chromosome 19q 13 region surrounding the apolipoprotein E (APOE) gene has shown consistent evidence of involvement in MS. In a cross-sectional study, to show the APOE genotype and allele frequency in the MS population of Iran in comp...

Internalization of apoE-containing very low density protein (VLDL) by hepatocytes in vivo and in vitro leads to apoE recycling and resecretion. Because of the role of apoE in VLDL metabolism, apoE recycling may influence lipoprotein assembly or remnant uptake. However, apoE is also a HDL protein, and apoE recycling may be related to reverse cholesterol transport. To investigate apoE recycling, ...

The apolipoprotein E (ApoE) gene has been linked to maladies such as hypercholesterolemia, CNS injury and disease. In this study, we present evidence that, in addition to the known transcript (ApoE S1) that translates into ApoE, there are three additional transcripts in mice. Two of these transcripts, ApoE S2 and ApoE S3, which are predicted to be transmembrane proteins, are transcribed from th...

Abstract APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to A? remains unclear. Here we report an isoform-specific phospholipid signature with correlation between human APOE?3/3 APOE?4/4 AD brain lipoproteins from astrocyte conditioned media of APOE3 APOE4 mice. Using preclinical mouse models, show that lipoproteins, unlike APOE...

The purpose of this study was to investigate the effects high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on skeletal muscle in Apolipoprotein E knockout (ApoE KO) wild-type (WT) C57BL/6J mice. ApoE KO mice fed with a high-fat diet were randomly allocated into: Control group without exercise (ApoE−/− CON), HIIT HIIT), MICT MICT). Exercise endurance, blood lipid p...