نتایج جستجو برای: چارچوب gof

تعداد نتایج: 18532  

2015
Yang Cai Xiang Yan Guoqing Zhang Weihong Zhao Shunchang Jiao

Cisplatin is one of the most common chemotherapeutic drugs for non-small cell lung cancer (NSCLC). However, the response rate is limited because of drug resistance. Histone deacetylase inhibitors (HDACis), which can alter DNA accessibility by regulating chromatin structure and inducing apoptosis, exhibit a synergistic action with cisplatin. However, no biomarkers that can predict the efficacy o...

Journal: :Advances in microbiology 2022

The present opinion article, while dealing with the debated origin of “Severe Acute Respiratory Syndrome-Coronavirus-2” (SARS-CoV-2), betacoronavirus responsible for “Corona Virus Disease-2019” (COVID-19), provides a speculative insight into so-called “gain function” (GOF), process resulting in acquirement new phenotypic features on behalf viral pathogen. More detail, GOF-related phenomenon lea...

Journal: :Genetics 2003
Jinghong Li Willis X Li

Overactivation of receptor tyrosine kinases (RTKs) has been linked to tumorigenesis. To understand how a hyperactivated RTK functions differently from wild-type RTK, we conducted a genome-wide systematic survey for genes that are required for signaling by a gain-of-function mutant Drosophila RTK Torso (Tor). We screened chromosomal deficiencies for suppression of a gain-of-function mutation tor...

2004
Lourens J. Waldorp Hilde M. Huizenga

To test whether the model fits the data well, a goodness-of-fit (GOF) test can be used. The chi-square GOF test is often used to test the null hypothesis that a function describes the mean of the data well. The null hypothesis with this test is rejected too often, however, because the nominal significance level (usually 0.05) is exceeded. Alternatively, the level of Hotelling’s test is accurate...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Lisa A Ehrman Diana Nardini Sarah Ehrman Tilat A Rizvi James Gulick Maike Krenz Biplab Dasgupta Jeffrey Robbins Nancy Ratner Masato Nakafuku Ronald R Waclaw

The protein tyrosine phosphatase Shp2 (PTPN11) is crucial for normal brain development and has been implicated in dorsal telencephalic neuronal and astroglia cell fate decisions. However, its roles in the ventral telencephalon and during oligodendrogenesis in the telencephalon remain largely unknown. Shp2 gain-of-function (GOF) mutations are observed in Noonan syndrome, a type of RASopathy asso...

2015
Anthony M. Barsotti Michael Ryskin Wenyan Zhong Wei-Guo Zhang Andreas Giannakou Christine Loreth Veronica Diesl Maximillian Follettie Jonathan Golas Michelle Lee Timothy Nichols Conglin Fan Gang Li Stephen Dann Valeria R. Fantin Kim Arndt Dominique Verhelle Robert A. Rollins

In addition to genetic alterations, cancer cells are characterized by myriad epigenetic changes. EZH2 is a histone methyltransferase that is over-expressed and mutated in cancer. The EZH2 gain-of-function (GOF) mutations first identified in lymphomas have recently been reported in melanoma (~2%) but remain uncharacterized. We expressed multiple EZH2 GOF mutations in the A375 metastatic skin mel...

Journal: :The Journal of General Physiology 2005
Andriy Anishkin Chien-Sung Chiang Sergei Sukharev

The tension-driven gating transition in the large mechanosensitive channel MscL proceeds through detectable states of intermediate conductance. Gain-of-function (GOF) mutants with polar or charged substitutions in the main hydrophobic gate display altered patterns of subconducting states, providing valuable information about gating intermediates. Here we present thermodynamic analysis of severa...

Journal: :Chemical communications 2013
Ehsan Pourazadi Enamul Haque Weimin Zhang Andrew T Harris Andrew I Minett

Herein, boronic acid is incorporated into a graphene oxide (GO) structure in order to synthesise a graphene organic framework (GOF) with enhanced electrochemical performance. The results obtained indicate that the GOF favours a 4e(-) reduction pathway in the oxygen reduction reaction (ORR).

2017
Ofer Zimmerman Berenice Rösler Christa S Zerbe Lindsey B Rosen Amy P Hsu Gulbu Uzel Alexandra F Freeman Elizabeth P Sampaio Sergio D Rosenzwieg Hye Sun Kuehn Tiffany Kim Kristina M Brooks Parag Kumar Xiaowen Wang Mihai G Netea Frank L van de Veerdonk Steven M Holland

Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

1997
James Noble

The Design Patterns book introduced twenty-three patterns for object oriented software design. These patterns are used widely, but only in their intended domain of software design. We describe how six of these patterns can be used for the conceptual design of graphical user interfaces. By using these patterns, designers can produce interfaces which are more consistent, make good use of screen s...

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