Phoslactomycins (PLMs) and related leustroducsins (LSNs) have been isolated from a variety of bacteria based on antifungal, anticancer, and other biological assays. Streptomyces sp. strain HK 803 produces five PLM analogs (PLM A and PLMs C to F) in which the C-18 hydroxyl substituent is esterified with a range of branched, short-alkyl-chain carboxylic acids. The proposed pathway intermediate, P...

Zhang XQ, Wang J, Carl LL, Song J, Ahlers BA, Cheung JY. Phospholemman regulates cardiac Na /Ca exchanger by interacting with the exchanger’s proximal linker domain. Am J Physiol Cell Physiol 296: C911–C921, 2009. First published January 21, 2009; doi:10.1152/ajpcell.00196.2008.—Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser, PLM inh...

The concept (and implementation) of Product Lifecycle Management (PLM) has drawn much attention in both industry and academia. This paper investigates the scope of PLM systems, presents different types of PLM architecture and identifies an appropriate definition of PLM for a Network-Centric Manufacturing paradigm with a specific focus on small manufacturing enterprises. Research issues of PLM s...

We present a new kind of pattern classifier, the Polynomial Learning Machine (PLM). The PLM is derived, and its construction detailed. We compare the performance of the PLM to that of the Support Vector Machine (SVM) in classifying binary-classed data sets, and find that the PLM consistently trains and tests in a shorter time than the SVM while maintaining comparable classification accuracy; in...

NCX1 (Na(+)/Ca(2+) exchanger 1) is an important regulator of intracellular Ca(2+) and a potential therapeutic target for brain ischaemia and for diastolic heart failure with preserved ejection fraction. PLM (phospholemman), a substrate for protein kinases A and C, has been suggested to regulate NCX1 activity. However, although several studies have demonstrated that binding of phosphorylated PLM...

Phospholemman (PLM, FXYD1), abundantly expressed in the heart, is the primary cardiac sarcolemmal substrate for PKA and PKC. Evidence supports the hypothesis that PLM is part of the cardiac Na-K pump complex and provides the link between kinase activity and pump modulation. PLM has also been proposed to modulate Na/Ca exchanger activity and may be involved in cell volume regulation. This study ...

Overexpression of phospholemman (PLM) in normal adult rat cardiac myocytes altered contractile function and cytosolic Ca2+ concentration ([Ca2+]i) homeostasis and inhibited Na+/Ca2+ exchanger (NCX1). In addition, PLM coimmunoprecipitated and colocalized with NCX1 in cardiac myocyte lysates. In this study, we evaluated whether the cytoplasmic domain of PLM is crucial in mediating its effects on ...

The FXYD protein family consists of several small, single-span membrane proteins that exhibit a high degree of homology. The best-known members of the family include the gamma-subunit of the Na(+)-K(+)-ATPase and phospholemman (PLM), a phosphoprotein of cardiac sarcolemma. Other members of the family include corticosteroid hormone-induced factor (CHIF), mammary tumor protein of 8 kDa (Mat-8), a...

The adoption of product lifecycle management (PLM) business approach requires the implementation of PLM systems. Currently there is a wide variety of PLM systems in the market, but the scope differences between existing systems hamper the selection process for manufacturing companies. This paper presents a reference model for PLM systems and discusses a preliminary proposal for the evolution of...