Prostaglandin F2α (PGF2α) is commonly given to female cattle intramuscularly (IM) for the synchronization of estrus. A novel site for administration of PGF2α that improves beef quality assurance is the ischiorectal fossa (IRF). The objective of this study was to determine whether administration of PGF2α in the IRF results in a similar physiologic response to administration of PGF2α given IM. Ye...

Prostaglandin F2α (PGF2α), oxytocin and gonadotropin releasing hormone (GnRH) have been used in bulls, rams, boars, stallions or rodents to increase sperm numbers in the ejaculate. Improving sperm quantity in the canine ejaculate would benefit all assisted reproductive techniques used in this species. The purpose of the present study was to evaluate the effects of PGF2α, oxytocin and GnRH on ca...

BACKGROUND AND OBJECTIVES Oxidative stress (OS) plays an important role in the pathophysiology of atrial fibrillation (AF) by amplifying the inflammatory cascade, wherein augmented inflammation facilitates the atrial electrical remodeling process. Few studies have investigated the possible link between systemic inflammation and OS in AF. SUBJECTS AND METHODS A total of 220 consecutive patient...

These studies sought to test the hypothesis that prostaglandin F2α(PGF2α)-stimulated phasic myometrial contractions are characterized by the activation of the phosphatidylinositol-signaling pathway resulting in the generation of cytosolic calcium oscillations. For the experiments described in this report rat myometrial tissue was used, after the tissue was loaded with fura 2, to perform cytosol...

The study aimed to evaluated the reproductive performance response to short term oestrus synchronization during the transition period. One hundred and sixty-five indigenous multiparous non-lactating goats were subdivided into the following six treatment groups for oestrus synchronization: NT control Group (N= 30), Fe-21d, FGA vaginal sponge for 21days+eCG at 19d; FPe11d, FGA 11d + PGF2α and eCG...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by fibroblast proliferation and excess deposition of extracellular matrix proteins in the lungs. As antiinflammatory therapies such as steroids or immunosuppressive agents do not improve disease progression, targets to block fibrogenesis per se are needed. Mice lacking cytosolic phospholipase A2, a key enzyme tr...

Polychlorinated biphenyls (PCBs) and phytoestrogens were found to affect contractions of bovine uterus. Prostaglandins (PG) F2α and E2 are also involved in the uterine contractility. Hence the aim of these studies was to investigate the effect of PCBs and some phytoestrogens on PG secretion from endometrial cells obtained on days 1–5 of the oestrous cycle. Cells were incubated in aerated atmosp...

OBJECTIVE Postpartum hemorrhage is most common cause of maternal mortality. Active management of third stage of labor minimizes the risk of postpartum hemorrhage. To compare the effect of methylergonovine and 15-methyl prostaglandin F2α (15-methyl PGF2α) in active management of third stage of labor. METHODS A randomized open labelled parallel study with 50 women in normal labor, 25 in each gr...

The present study was performed to determine the effect of PGF2α and GnRH injections in different time intervals on fertility in Hair goats during breeding season. Totally, 80 primiparous Hair goats were divided into four groups (n=20 in each) according to the body condition scores of the animals. The animals in groups were treated as follows; first group (Ovsynch), GnRH on day 0, PGF2α on day ...

OBJECTIVE To investigate the potential of 8-iso-prostaglandin F2α (8-iso-PGF2α) as a biomarker for disease activity and oxidative stress in the CSF of patients with multiple sclerosis (MS). METHODS The isoprostane 8-iso-PGF2α is an established biomarker for in vivo oxidative stress and lipid peroxidation. We measured CSF 8-isoPGF2α levels in 231 patients with MS (74 with relapsing-remitting M...