The matrix metalloproteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remodeling. However, broad-spectrum MMP inhibition (MMPi), particularly inhibition of interstitial collagenase (MMP-1), may not be clinically applicable. This study examined the effects of selective MMPi (sparing MMP-1) in a model of developing congestive heart failure. Pigs were ...

This study assessed aspects of the construct validity of the Multidimensional Personality Questionnaire (MPQ), a measure of normal personality characteristics, in a clinically relevant sample through joint factor analyses of primary and second-order scales of the MPQ and the Minnesota Multiphasic Personality Inventory (MMPI). A subsample from the Washington University Twin Study of Psychopathol...

The validity of test data from multiscale inventories is dependent on self-reports that may be easily distorted by malingering. In examining the Minnesota Multiphasic Personality Inventory-2's (MMPI-2) role in the assessment of feigning, this review provides a conceptual analysis of the detection strategies underlying the MMPI-2 validity scales. The conceptual analysis is augmented by comprehen...

The development of congestive heart failure (CHF) is associated with left ventricle (LV) dilation and myocardial remodeling. The matrix metalloproteinases (MMPs) play a significant role in extracellular remodeling, and recent studies have demonstrated increased MMP expression and activity with CHF. Whether increased MMP activity directly contributes to the LV remodeling with CHF remains unknown...

The Minnesota Multiphasic Personality Inventory-2 is a broadband measure of psychopathology and personality that has a long tradition in assessment of medical patients. Beginning in the 1940’s the MMPI was used in the study of psychological factors in medical conditions and an extensive research base for the MMPI, and its successor the MMPI-2, in medical applications has developed. The current ...

In this comment, I address a number of the points raised in the reviews of the MMPI-2 Restructured Clinical (RC; Tellegen et al., 2003) Scales by Nichols (2006/this issue) and Rogers, Sewell, Harrison, and Jordan (2006/this issue), and I advocate for changes in assessment validation research. There is little evidence that the "syndromal complexity" Nichols ascribes to the original MMPI-2 (Butch...

Two previous meta-analyses concluded that average validity coefficients for the Rorschach and the MMPI have similar magnitudes (L. Atkinson, 1986; K. C. H. Parker, R. K. Hanson, & J. Hunsley, 1988), but methodological problems in both meta-analyses may have impeded acceptance of these results (H. N. Garb, C. M. Florio, & W. M. Grove, 1998). We conducted a new meta-analysis comparing criterionre...

The current study investigates the extent to which the Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) profiles of 196 male adolescents evaluated in a South Carolina detention center could be successfully discriminated from the protocols of 200 male adolescent psychiatric inpatients in three states and 151 dually diagnosed male adolescents. Results showed significant differences...