LINGO-1 (leucine-rich repeat and Ig domain containing NOGO receptor interacting protein-1) is a negative regulator of myelination and repair of damaged axons in the central nervous system (CNS). Blocking LINGO-1 function leads to robust remyelination. The anti-LINGO-1 Li81 antibody is currently being evaluated in clinical trials for multiple sclerosis (MS) and is the first MS therapy that direc...

Original scientific paper This paper presents a hybrid genetic algorithm for assembly flow-shop scheduling problem with sequence-dependent setup and transportation times, with objectives, namely the minimizing of weighted, sum of total weighted squared tardiness, makespan, and total weighted squared earliness and number of tardy jobs. Since the problem is NP-hard, we solved this problem by hybr...

This paper shows how to generate an English step-bystep explanation that describes how an automated reasoning system solves a complex constraint program. We study programs that solve tabular-constraint problems encoded in Constraint Lingo and then translated into propositional logic with cardinality constraints. We instrument the logic solver so that it generates log files. We inspect those log...

We argue that database query languages can be used to specif’y constraint satisfaction problems. We describe one such language here. It is based on tuple relational calculus and its sentences are used to define constraints. For a fragment of this language we develop a front end, Constraint Lingo, to facilitate programming tasks. Finally, we show that programs in Constraint Lingo can be compiled...

This study addressed warehouse storage location assignment problems (SLAP) to minimize total travelling distances in an order-picking process. The problem was formulated and presented as a mixed integer programming model. The LINGO optimization solver was then used to find solutions for a set of generated problems. The results showed that the LINGO optimization solver easily attained optimal so...

Postnatal administration of phencyclidine (PCP) in rodents causes major disturbances to neurological processes resulting in severe modifications to normal behavioral traits into adulthood. It is routinely used to model psychiatric disorders such as schizophrenia, producing many of the dysfunctional processes in the brain that are present in this devastating disorder, including elevated levels o...

Unraveling the causes underlying Alzheimer's disease (AD) is certainly one of the greatest challenges of this century for researchers. With advances in medicine and technology, the world is experiencing a demographic shift towards a growing elderly population. With this increasingly ageing population, the number of individuals being affected by AD is booming. AD has a significant negative impac...

The growing population in Puebla City these last couple of years entailed the expansion of its original urban area. The most recent settlements have established on areas that are highly exposed to natural disasters, thus, requiring the proper emergency service coverage provided by Fire Stations. To assure this kind of service coverage, the current fire stations in Puebla City were evaluated thr...

Abstrak Daerah Irigasi Cidurian terus mengalami pengurangan lahan, disebabkan pembangunan yang pesat di daerah Kabupaten Tangerang. Volume ketersediaan air semakin terbatas dan musim kemarau panjang juga menjadi salah satu penyebab kekuranga tanaman. Tanaman biasa dibudidayakan yaitu Padi Palawija dengan penyusunan pola tata tanam sudah ditetapkan. Penelitian ini bertujuan untuk mengetahui luas...