We estimate analytically the critical coupling separating the weak and the strong coupling regime in 4D simplicial quantum gravity to be located at kcrit 2 ≃ 1.3093. By carrying out a detailed geometrical analysis of the strong coupling phase we argue that the distribution of dynamical triangulations with singular vertices, dominating in such a regime, is characterized by distinct sub-dominatin...

Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-N4,N9-dioleoylspermine and N1,N12-diamidino-N4-linoleoyl-N9-oleoylspermine, were more efficient in terms of GFP expression reduction compared ...

The purpose of this study was to develop an efficient way to synthesize (99m)Tc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-tyrosine ((99m)Tc-N4-Tyrosine), a novel amino acid-based radiotracer, and evaluate its potential in breast cancer gamma imaging. Precursor N4-Tyrosine was synthesized using a 5-step procedure, and its total synthesis yield was 38%. It was successfully labeled with (9...

Samples were selected at two different times. At first sampling, populations were from staff nurses who were just classified as N1, N2, N3 and N4 level according to the clinical ladder system. Samples were randomly selected from N1 and N2, N3 level subjects and N4 subjects were all selected as samples. Sample sizes were 416, and 321 questionnaires returned were usable. At second sampling, popul...

In the title compound, [Zn(C(7)H(11)O(2))(C(10)H(9)N(3))(2)]NO(3)·H(2)O, the Zn(II) atom is five-coordinated by two bidentate di-2-pyridylamine ligands and one O atom from a cyclo-hexa-necarboxy-ate anion, resulting in a ZnON(4) square-based pyramidal coordination for the metal ion with the O atom in one of the basal positions. In the crystal, the components inter-act by way of O-H⋯O, O-H⋯N and...

We have purified and characterized a single-stranded DNA binding protein (N4 SSB) induced after coliphage N4 infection. It has a monomeric molecular weight of 31,000 and contains 10 tyrosine and 1-2 tryptophan amino acid residues. Its fluorescence spectrum is dominated by the tyrosine residues, and their fluorescence is quenched when the protein binds single-stranded DNA. Fluorescence quenching...