GTP cyclohydrolase I feedback regulatory protein (GFRP) is a 9.7-kDa protein regulating GTP cyclohydrolase I activity in dependence of tetrahydrobiopterin and phenylalanine concentrations, thus enabling stimulation of tetrahydrobiopterin biosynthesis by phenylalanine to ensure its efficient metabolism by phenylalanine hydroxylase. Here, we were interested in regulation of GFRP expression by pro...

Glass fiber reinforced polymer (GFRP) pultruded profiles are being increasingly used in civil engineering applications. Although they offer several advantages over traditional materials, such as high strength, lightness and non-corrodibility, GFRP profiles present low elasticity and shear moduli, which together with their slender walls makes them very prone to buckling phenomena. Several previo...

This research paper compares the thermal conductivity and thermal expansion coefficients of glass fiber reinforced epoxy composite laminates (GFRP laminates) made using the Hand layup technique. The composite laminates were fabricated by filling with varying concentrations of fly ash, stone powder, aluminium oxide (Al2O3), magnesium hydroxide (Mg (OH)2), Silicon carbide particles(SiC) and hemat...

Investigations on flexural and tensile properties of GFRP laminates influenced by stainless steel wire reinforcement were carried out as a novel approach. Plain GFRP laminates and GFRP laminates reinforced with stainless steel wires at different depth with various pitch distances were fabricated by hand layup method. The composite specimens reinforced with steel wires were exposed to low freque...

BACKGROUND AND PURPOSE 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4 has limited efficacy. Therefore, orally bioavailable pharmacological activators of endogenous BH4 biosynthesis hold significant therapeutic poten...

Fiber reinforced polymer materials are continuing to show great promise for using strengthening reinforced concrete structures. These materials are an excellent option for use as external reinforcing, because of their light weight, resistant to corrosion and high strength. The main aim of this study is to investigate the flexural characteristic of RC beams using GFRP sheets and strips. This pap...

Glass fibre reinforced polymer (GFRP) profiles are finding increasing applications in civil engineering structures, owing to the several advantages they offer over traditional materials. However, due to the combustible nature of their polymer matrix, there are well-founded concerns about their behaviour at elevated temperature and under exposure to fire. These concerns are hindering the widespr...

A novel real-time radar NDE technique for the in-depth inspection of glass fiber reinforced polymer (GFRP)retrofitted concrete columns is proposed. In this technique, continuous wave radar signals are transmitted in the far-field region (distant inspection), and reflected signals are collected by the same signal transmitter. Collected radar signals are processed by tomographic reconstruction me...

Glass fiber-reinforced polymer (GFRP) concrete reinforcement exhibits high strength, is lightweight, can decrease time of construction, and is corrosion resistant. However, research has shown that chemical reactions deteriorate the GFRP reinforcing bars over time, resulting in a reduced tensile capacity. This paper develops a time-variant probabilistic model to predict the tensile capacity of G...