normal 0 false false false en-us x-none fa background : the aim of the study was to assess the effects of combination of bortezomib moderate dose and continuous oral low dose melphalan and thalidomide and dexamethasone (bmtd regimen) in elderly patients aged ≥ 65 years with relapsed multiple myeloma (mm). methods : twenty four patients with advanced mm were enrolled to receive eight 3-week trea...

Multiple myeloma is a monoclonal malignant proliferation of plasma cells. The disease is more frequent in men, and the average age of patients at the time of diagnosis of the disease is about 60 years. Solitary myeloma may be the first manifestation of the disseminated form of multiple myeloma, which is characterized by multiple skeletal lesions, general metabolic alterations, impairment of ren...

Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of S...

multiple myeloma is a monoclonal malignant proliferation of plasma cells. the disease is more frequent in men, and the average age of patients at the time of diagnosis of the disease is about 60 years. solitary myeloma may be the first manifestation of the disseminated form of multiple myeloma, which is characterized by multiple skeletal lesions, general metabolic alterations, impairment of ren...

A 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. Then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. His bone marrow asp...

introduction: plasmacytoma is a monoclonal proliferation of plasma cells. it can be an isolated lesion, for which the term extramedullary plasmacytoma is used, or a representation of multiple myeloma.the upper respiratory tract is the most common site for an extramedullary plasmacytoma. sinonasal plasmacytomas cause different symptoms depending on the sites of origins and the areas of involveme...

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multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...

introduction: multiple myeloma is a neoplasm of monoclonal plasmacells which may cause oral manifestations. we report a 50-year-old man with a mass burned out of a post extraction socket. he had recived an eight month period of chemotherapy and was supposed to be ready for hematopoetic stem cell transplantation. after clinical and histopathological examinations, the mass was diagnosed as a plas...

second primary malignancy following multiple myeloma (mm) was reported several years ago. there are also rare reports of cases with synchronous mm and other malignancies. to our knowledge, only one case of mm following bladder cancer has been reported in the literature. here, we report the second case occurred three months after diagnosis of bladder cancer.