OBJECTIVE To explore the relationship between single nuclear polymorphisms (SNPs) in ectodysplasin A receptor (EDAR) and EDAR-associated death domain (EDARADD) genes and non-syndromic tooth agenesis. METHODS Ten putative SNPs in EDAR and EDARADD were selected, and a case-control study was conducted in 112 subjects with non-syndromic tooth agenesis and 112 normal control subjects. DNA was obta...

PURPOSE The objectives of this study were to investigate the prevalence and characteristics of tooth agenesis and the associated skeletal morphology and arch widths in a group of Turkish patients seeking orthodontic treatment. MATERIAL AND METHODS We designed a retrospective study composed of pre- and post-treatment panoramic radiographs and lateral cephalometric films of 3,341 patients (2,04...

Congenital tooth agenesis in human is characterized by failure of tooth development during tooth organogenesis. 300 genes in mouse and 30 genes in human so far have been known to regulate tooth development. However, candidature of only 5 genes viz. PAX9, MSX1, AXIN2, WNT10A and EDA have been experimentally established for congenitally missing teeth like hypodontia and oligodontia. In this study...

OBJECTIVE To determine the prevalence of hypodontia in the general population and orthodontic population in adolescent Chinese Hans. METHODS Two groups named the general population (6015 subjects) and the orthodontic population (2781 subjects) were investigated, respectively. The former came from the students of three general universities in North China and the latter came from patients comin...

Irf6 (interferon regulatory factor 6) is expressed in tooth buds and palatine rugae during development in the mouse. Here we report the first study to investigate whether IRF6 variation is associated with palatine rugae patterns in a population with sporadic tooth agenesis. Fifty-two individuals with sporadic tooth agenesis and their parents were studied. Palatine rugae were scored from casts a...

The etiology of tooth agenesis may be related to several factors, among them, the genetic alterations that play a fundamental role in the development of this dental anomaly, so that knowledge about it helps the clinician to have a greater understanding of their patients. Thus, the aim of this study was to report the case of a nonsyndromic child, with tooth agenesis of one premolar, three first ...

WNT10A is a signaling molecule involved in tooth development, and WNT10A defects are associated with tooth agenesis. We characterized Wnt10a null mice generated by the knockout mouse project (KOMP) and six families with WNT10A mutations, including a novel p.Arg104Cys defect, in the absence of EDA,EDAR, or EDARADD variations. Wnt10a null mice exhibited supernumerary mandibular fourth molars, and...

STATEMENT OF PROBLEM Agenesis of the maxillary lateral incisor has been linked to differences in the size of the remaining teeth. Thus, the mesiodistal space required for definitive esthetic restoration in patients with missing maxillary lateral incisors may be reduced. PURPOSE The purpose of this study was to determine whether a tooth size discrepancy exists in orthodontic patients with agen...

Agenesis of one or more teeth is the most common anomaly in dental development.1 The incidence for permanent tooth agenesis ranges from 1.6 to 9.6% in the general population excluding third molars.2-6 Third molars being the most commonly missing tooth, opinions vary on the second most commonly missing tooth. Some investigators7-11 believe that this is the maxillary lateral incisor whereas other...