Interphase cultured monkey kidney (TC-7) cells contain distinct subsets of cellular microtubules (MTs) enriched in posttranslationally detyrosinated (Glu) or tyrosinated (Tyr) alpha tubulin (Gundersen, G. G., M. H. Kalnoski, and J. C. Bulinski. 1984. Cell. 38:779-789). To determine the relative stability of these subsets of MTs, we subjected TC-7 cells to treatments that slowly depolymerized MT...

The mts-1 gene is associated with the expression of the metastatic phenotype of tumor cells. The protein product of the mts-1 gene belongs to the S100 family of Ca(2+)-binding proteins with unknown biochemical function. In the present work, monoclonal anti-Mts-1 antibodies were used to isolate and characterize Mts-1 protein possible targets. Mts-1 protein can be immunoprecipitated by both anti-...

Background & Aims: The Modified Tardieu Scale (MTS) is a clinical scale for measuring the degree of muscle spasticity. The aim of this study was to evaluate the validity of the MTS in measuring poststroke knee extensorspasticity. Methods: This was a cross-sectional study performed in 2012 at a university clinic of neurological physiotherapy in Tehran, Iran, with repeated measurements. In the pr...

Microtubules (MTs) are important cytoskeletal structures engaged in a number of specific cellular activities, including vesicular traffic, cell cyto-architecture and motility, cell division, and information processing within neuronal processes. MTs have also been implicated in higher neuronal functions, including memory and the emergence of "consciousness". How MTs handle and process electrical...

Microtubules (MTs) are fibrous and tube-like cell substructures exist in cytoplasm of cells which play a vital role in many cellular processes. Surface effects on the vibration of bioliquid MTs surrounded by cytoplasm is investigated in this study. The emphasis is placed on the effect of the motor protein motion on the MTs. The MT is modeled as an orthotropic beam and the surrounded cytoplasm i...

All TV-video systems receive and/or process the audio portion of the TV signal. The audio circuits may receive only the monaural portion or may decode the MTS stereo and SAP audio signals as well. The Electronics Industry Association (EIA) reports that sales of MTS Stereo TV receivers have enjoyed six straight years of double digit increases. MTS Stereo decoder circuits are now virtually standa...

We present a computational model to test a "polarity sorting" mechanism for microtubule (MT) organization in developing axons. We simulate the motor-based axonal transport of short MTs to test the hypothesis that immobilized cytoplasmic dynein motors transport short MTs with their plus ends leading, so "mal-oriented" MTs with minus-end-out are transported toward the cell body while "correctly" ...

BACKGROUND AND PURPOSE We objectively assessed surface structural changes of the hippocampus in mesial temporal sclerosis (MTS) and assessed the ability of large-deformation high-dimensional mapping (HDM-LD) to demonstrate hippocampal surface symmetry and predict group classification of MTS in right and left MTS groups compared with control subjects. METHODS Using eigenvector field analysis o...

We have proposed that microtubules (MTs) destined for axons and dendrites are nucleated at the centrosome within the cell body of the neuron, and are then released for translocation into these neurites (Baas, P. W., and H. C. Joshi. 1992. J. Cell Biol. 119:171-178). In the present study, we have tested the capacity of the neuronal centrosome to act as a generator of MTs for relocation into othe...

ow microtubules (MTs) 1 influence secretion has long intrigued cell biologists. Significant insight has come from studies showing that MTs serve as highways along which transport intermediates travel between the ER and Golgi (9, 10, 21, 28, 32), making it tempting to conclude that MTs are essential for secretion. While the literature contains many additional reports supporting that view (for ex...