In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete...

Heparin-binding growth-associated molecule (HB-GAM) is an extracellular matrix-associated protein implicated in the development and plasticity of neuronal connections of brain. Binding to cell surface heparan sulfate is indispensable for the biological activity of HB-GAM. In the present paper we have studied the structure of recombinant HB-GAM using heteronuclear NMR. These studies show that HB...

HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth factors. It promotes axonal growth from perinatal rat brain neurons and is suggested to be mitogenic for some cell types and to display cell-transforming activity...

The density fluctuation of Geodesic Acoustic Mode (GAM) zonal flow has been observed in Ohmic deuterium plasma discharges with Langmuir probe arrays on the HL-2A tokamak. The density fluctuation has the poloidal mode number m < 1 and toroidal mode number n ~ 0. Its amplitude is consistent with theoretic prediction as well. Bispectral analysis shows that the nonlinear interaction between the GAM...

This paper describes the use of the GAM procedure for fitting generalized additive models (Hastie and Tibshirani, 1990). PROC GAM, production in Release 8.2, provides an array of powerful tools for data analysis, incorporating nonparametric regression and smoothing techniques as well as generalized distributional modeling. Compared with other regression procedures such as PROC REG and PROC GLM,...

The TSR (thrombospondin type I repeat) is defined by a conserved tryptophan/cysteine motif and found in a large family of extracellular matrix and cell surface proteins (for review, see [1]). These proteins include thrombospondins 1 and 2, F-spondin, mindin, and semaphorins F and G. HB-GAM (heparin-binding growth-associated molecule, also designated as pleiotrophin) and MK (midgestation-kidney ...

A theory of the effect of the geodesic acoustic mode !GAM" on turbulence is presented. Two synergistic issues are elucidated: namely, the physics of the zonal flow modulation and its role in the L-H transition, and the role of the GAM wave group propagation in turbulence spreading. Using a wavekinetic modulational analysis, the response of the turbulence intensity field to the GAM is calculated...

This paper proposes a general associative memory (GAM) system that combines the functions of other typical associative memory (AM) systems. The GAM is a network consisting of three layers: an input layer, a memory layer, and an associative layer. The input layer accepts key vectors, response vectors, and the associative relationships between these vectors. The memory layer stores the input vect...

Gentisamide (GAM, 2,5-dihydroxybenzamide), a minor first-pass metabolite of salicylamide (SAM, 2-hydroxybenzamide), was studied using FT-IR, 1D and 2D homo- and heteronuclear 1H and 13C NMR spectroscopy. GAM was isolated from human urine eight hours after oral administration of SAM. FT-IR, 1H and 13C NMR spectra unequivocally confirmed the chemical structure of GAM through chemical and substitu...

Nowadays, companies are investing in a well-considered CRM strategy. One of the cornerstones in CRM is customer churn prediction, where one tries to predict whether or not a customer will leave the company. This study focuses on how to better support marketing decision makers in identifying risky customers by using Generalized Additive Models (GAM). Compared to Logistic Regression, GAM relaxes ...