BCG is the only vaccine presently available against tuberculosis but it is estimated to prevent only 5% of the all potentially vaccine-preventable deaths due to Tuberculosis. Keeping these in view the present study has been undertaken to evaluate the efficacy of BCG and the effect of repeat dose of BCG on antimycobacterial humoral response in mouse model. To improve BCG immunogenicity, specific...

Purpose: Bacillus Calmette-Guérin (BCG) intravesical therapy is the standard treatment in high-risk patients with non-muscle-invasive bladder cancer, but a significant number of patients experience recurrence after BCG therapy. Although several treatment options are available for recurrence after BCG therapy, the optimal treatment strategy is still controversial. We reviewed current and promisi...

The effect of exposure to diesel exhaust particulate (DEP) on bacillus Calmette-Guerin (BCG) lung infection in mice was studied. C57Bl/6J female mice were infected with BCG (2.5 x 104 bacteria/mouse) by intrapulmonary instillation, with or without coadministration of DEP (100 microg/mouse). Five weeks later, mice exposed to DEP + BCG had about a four-fold higher BCG load in the lungs than mice ...

The policy of vaccinating children who live with leprosy patients, and who have responses to leprosin A of2rnrn or less, with BCG+killed Mycobacterium vaccae if they lack a BCG scar, or with killed M. vaccae alone if they have a BCG scar, has been followed over 3-4 years in two centers in Iran. Judged on the basis of skin test conversion to leprosin positivity, the policy has been highly su...

conclusions subcutaneous nodules in the absence of a local reaction at the site of bcg vaccination may be the sole manifestation of disseminated bcg disease. case presentation we report on an 11-months-old boy with prolonged fever and diffuse hyperpigmented subcutaneous nodules. due to lymphopenia, oral thrush and severe adverse reaction to bcg vaccination, the possibility of primary immunodefi...

BACKGROUND BCG vaccination is recommended at birth in low-income countries, but vaccination is often delayed. Often 20-dose vials of BCG are not opened unless at least ten children are present for vaccination ("restricted vial-opening policy"). BCG coverage is usually reported as 12-month coverage, not disclosing the delay in vaccination. Several studies show that BCG at birth lowers neonatal m...

Tuberculosis is an important disease in the world especially in developing and undeveloped regions and PPD test is the standard test for diagnosis of this infectious disease [1-3]. BCG vaccination has proven to be the most effective technique for controlling tuberculosis in the world especially in developing countries [1]. The BCG vaccination is the most extensively used immunization worldwide,...

A component of Mycobacterium bovis BCG referred to as BCG-a was isolated through the combined use of monoclonal antibody directed to BCG and affinity chromatography. Analysis of BCG-a by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed a single prominent band with a molecular weight of ca. 10,000. Structural characterization of BCG-a consisting of amino acid composition and am...