Mice bearing TEPC-183, an immunoglobulin (M(ic)-secreting plasmacytoma, exhibit severe suppression of their immune responses. Since chemotherapy with cyclophosphamide (CY) is used in the treatment of myeloma, the present study was undertaken to determine its effect on the immune response. CY was tested at different doses in order to establish whether a tumor-lytic dose could be established whic...

The effect of combined cyclophosphamide (CY) and heat treatments on a murine tumor was studied at various temperatures. FSa-II tumors, the early generation isotransplants of a spontaneous fibrosarcoma in a C3Hf/Sed mouse, were used. A single cell suspension was transplanted into the animal foot. Hyperthermia was given by immersing animal feet into a water bath maintained at a desired temperatur...

An electron-transfer series of octahedral α-diimine complexes [((H)L(Cy))3Cr](n+)(BARF)n (n = 2, 1, 0) has been synthesized and crystallographically characterized. Cyclic voltammetry indicated additional formation of [((H)L(Cy))3Cr](3+). The molecular structures suggested that all redox processes were ligand-based. Magnetic moments were consistent with spin ground states of S = 0 for [(H)L(Cy)3...

Hemorrhagic cystitis and diffuse inflammation of the bladder, common side effects of cyclophosphamide (CY) treatment, have been linked to the generation of acrolein derived from CY metabolism. Metabolic removal of acrolein involves multiple pathways, which include reduction, oxidation, and conjugation with glutathione. Herein, we tested the hypothesis that glutathione S-transferase P (GSTP), th...

The synthesis of 16-electron complexes of the type (Cy-PSiP)RuX(L) (Cy-PSiP = κ3-(2-Cy2PC6H4)2SiMe) is reported. Treatment of (Cy-PSiP)H with one equiv. RuCl2(PPh3)3 in the presence of Et3N afforded a mixture of (Cy-PSiP)RuCl(PPh3) (1) and [(Cy-PSiP)RuCl]2 (2), which exists in a temperature-dependent equilibrium process involving reversible dissociation of PPh3 from 1 to form 2. While treatment...

Cyclophosphamide (CY) has been shown to modulate a number of immune responses. In the present study, we have examined the effect of CY on human natural killer (NK) cells in vitro. Lymphocytes from six normal volunteers were cultured alone or with CY in the medium containing human AB plasma, and their cytotoxicity was assessed against cells of K562. The results demonstrated that lymphocytes when...

HSCT from an unrelated HLA-mismatched donor (MMUD) is one of the alternatives where HLA-matched not found. The aim this study was to compare GvHD prophylaxis with anti-thymocyte globulin (ATG) vs. post-transplant cyclophosphamide (PT-Cy). Thirty-nine adult patients were uniformly treated rabbit ATG-Cy-A-MTX and peripheral blood stem cell (PBSC) 40 PT-Cy-MMF-tacrolimus PBSC. This retrospective r...