The availability of long circulating, multifunctional polymers is critical to the development of drug delivery systems and bioconjugates. The ease of synthesis and functionalization make linear polymers attractive but their rapid clearance from circulation compared to their branched or cyclic counterparts, and their high solution viscosities restrict their applications in certain settings. Here...

UNLABELLED HPG Aligner applies suffix arrays for DNA read mapping. This implementation produces a highly sensitive and extremely fast mapping of DNA reads that scales up almost linearly with read length. The approach presented here is faster (over 20× for long reads) and more sensitive (over 98% in a wide range of read lengths) than the current state-of-the-art mappers. HPG Aligner is not only ...

Incorporation of unnatural amino acids into recombinant proteins represents a powerful tool for protein engineering and protein therapeutic development. While the processing of the N-terminal methionine (Met) residues in proteins is well studied, the processing of unnatural amino acids used for replacing the N-terminal Met remains largely unknown. Here we report the effects of the penultimate r...

This work aims to verify whether Galvanic Skin Response (GSR) can be used as a valid pain indicator and to analyze the changes in GSR during hypnotic analgesic condition. Two types of experiments were conducted namely ‘Pain-GSR’ (PG) and ‘Hypnosis-Pain-GSR’ (HPG) experiments for 10 subjects. The experiments were done under pain and no-pain conditions on subjects of both the gender in the age gr...

Energy deficiency can suppress reproductive functions in vertebrates. As the orchestrator of reproductive function, endocrine activity of the hypothalamo-pituitary-gonadal (HPG) axis is potentially an important mechanism mediating such effects. Previous experiments in wild-caught birds found inconsistent relationships between energy deficiency and seasonal reproductive function, but these exper...

The hypothalamic-pituitary-gonadal (HPG) axis exerts a profound effect on animal development, reproduction, and response to stress, and new insights into its complicated functional activities are continuously being made. In the present study, by using immunohistochemical studies and different mouse models (ovariectomy and ob/ob mice), we systemically analyzed the expression of a novel mitochond...

El objetivo de esta investigación fue determinar la prevalencia parásitos gastrointestinales en caballos durante el periodo cuarentena 2011 Hipódromo “La Rinconada”, Caracas, Venezuela. Se realizó un estudio coprológico por técnica flotación Mc master (Willis-Molloy) a total 894 equinos (Equus caballus), raza Pura Sangre Carrera, 400 sexo macho y 494 hembras, todos 2 años edad, procedentes cent...

Temperature-triggered copolymers are proposed for a number of bio-applications but there is no ideal material platform, especially for injectable drug delivery. Options are needed for degradable biomaterials that not only respond to temperature but also easily accommodate linkage of active molecules. A first step toward realizing this goal is the design and synthesis of the novel materials repo...

nano sio2/hyperbranched polyglycerol (hpg)/so3h catalyst was readily prepared for first time from inexpensive starting materials in aqueous media which catalyzed the synthesis of benzoic acid. ftir spectra, x-ray diffraction (xrd) and transmission electron micrographs (tem) was employed to characterize the properties of the synthesized nano sio2/hpg/so3h. high catalytic activity and ease of rec...

PURPOSE The present work describes the development and in vitro and in vivo evaluation of a mucoadhesive nanoparticulate docetaxel (DTX) formulation for intravesical bladder cancer therapy. EXPERIMENTAL DESIGN Mucoadhesive formulations based on hyperbranched polyglycerols (HPG), hydrophobically derivatized with C(8)/C(10) alkyl chains in the core and modified with methoxy-polyethylene glycol ...