The androgen receptor (AR) is a member of the superfamily of nuclear receptors (NRs) that regulate gene expression in a ligand-dependent manner. Selective androgen receptor modulators (SARMs) are ligands that activate AR in a tissue-selective manner to produce unique physiological effects. To investigate the mechanism responsible for SARM tissue-selectivity, the conformation of AR while bound t...

Gold nanorods (GNRs) are of particular interest for biomedical applications due to their unique size-dependent longitudinal surface plasmon resonance band in the visible to near-infrared. Purified GNRs are essential for the advancement of technologies based on these materials. Used in concert, asymmetric-flow field flow fractionation (A4F) and single particle inductively coupled mass spectromet...

Methods Two groups of patients with triple-vessel coronary disease were evaluated. Each group consisted of 15 patients,aged between 40 and 70, 70% being males and 30% females.The patients in both groups had similar systolic left ventricular function and some degree of diastolic dysfunction. Group I patients had standard postoperative medical treatment, and in Group II supplemental therapy with ...

OBJECTIVES To develop and test the psychometric properties of an Arabic version of Fatigue Severity Scale (FSS-Ar) that can be used to measure fatigue in Arabic patients with disorders where fatigue is a major symptom.  METHODS Forward and backward translations of FSS were undertaken to develop an Arabic version. The validity and reliability of the FSS-Ar was then tested on 28 patients with s...

BACKGROUND Rheumatic heart disease (RHD) is the commonest acquired heart disease in children worldwide but in Uganda, data is scarce regarding its morbidity and mortality. The disease has a progressive course and patients usually require valve repair/replacement in the future. OBJECTIVES To describe the frequency of echocardiographic valvular dysfunction in children with RHD To explore the re...

The IGSTK (Image-Guided Surgery Toolkit) library is a free and open toolkit for the development of prototype surgical navigation applications. IGSTK contains all necessary modules required for surgical 2D and 3D visualization, DICOM data import, various 3D-tracking systems and handling of live-video input directly or over a network. IGSTK was added a new component for real-time, interactive aug...

Multiple Sclerosis (MS) is a chronic, incurable disease of the central nervous system that also one most common causes disability among young adults. Despite available pharmacological treatments, patients often require ongoing, supervised rehabilitation. Thus, therapists are constantly searching for new, effective ways improving functional performance and quality life without frequently visitin...

normal 0 false false false en-us x-none ar-sa epilepsy is more common in patients with multiple sclerosis (ms) than in the general population, occurring in 2%–3% of patients. convulsions may be either tonic–clonic in nature or partial complex. in these individuals, seizures most likely result from lesions present in the cerebral cortex and subcortical white matter. a jacksonian seizure is a typ...