Muscle blood flow (MBF) and muscle oxygen saturation (SmO(2)) were measured at eight locations (four proximal, four distal) over a 4 x 8 cm(2) area of the vastus lateralis at rest and immediately after isometric, maximal quadriceps contraction using multichannel, frequency-domain, near-infrared spectroscopy. A venous occlusion was applied 20 s before the end of the exercise, so that the venous-...

Insulin mucoadhesive buccal films (MBF) are a noninvasive insulin delivery system that offers an advantageous alternative route of administration to subcutaneous injection. One major concern in the formulation MBF is preservation secondary structure presence other film components. Buccal were formulated using chitosan, glycerin, and L-arginine. The MBF-forming solutions (MBF-FS) examined for th...

UNLABELLED (82)Rb cardiac PET allows the assessment of myocardial perfusion with a column generator in clinics that lack a cyclotron. There is evidence that the quantitation of myocardial blood flow (MBF) and coronary flow reserve (CFR) with dynamic (82)Rb PET is feasible. The objectives of this study were to determine the accuracy and reproducibility of MBF estimates from dynamic (82)Rb PET by...

OBJECTIVES We evaluated the maximum occlusal bite force (MBF) among individuals with fixed partial dentures compared to the opposite dentate side and determined the relationship between MBF and gender, age, and body mass index (BMI). SUBJECTS AND METHODS A total of 85 subjects (43 males and 42 females, age range 28-66 years) with fixed partial dentures on one side and dentate on the other sid...

INTRODUCTION We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHO...

UNLABELLED PET absolute myocardial blood flow (MBF) with H(2)15O and 13NH3 are widely used in clinical and research settings. However, their reproducibility with a 16-myocardial segment model has not been examined in chronic coronary artery disease (CAD). We examined the short-term reproducibility of PET H(2)15O MBF and PET 13NH3 MBF in an animal model of chronic CAD. METHODS Twelve swine (me...

Background Pixel-wise quantitative analysis of cardiovascular magnetic resonance (CMR) perfusion images allows myocardial blood flow (MBF) to be measured at the level of approximately 30 μL of myocardium. However B1-field inhomogeneity, induced by phased array surface receiver coils, potentially confounds MBF measurements. The aim of this study was to compare the effect of: 1. no surface coil i...

Endothelin-1 (ET-1) produces potent renal effects that we have previously shown to be dependent on cytochrome P-450 (CYP450) metabolites of aracidonic acid (24) This study evaluated the role of these metabolites in the effects produced by ET-1 on renal blood flow (RBF), cortical blood flow (CBF), medullary blood flow (MBF), and mean arterial blood pressure (MBP). ET-1 (20-200 pmol/kg) increased...

OBJECTIVE To determine whether cardiac rehabilitation influences plasma levels of angiogenic cytokines and their correlation with myocardial blood flow (MBF). DESIGN Randomised controlled study. SETTING Tertiary cardiac centre. PATIENTS 39 postinfarction patients randomised to either a 3-month training group (n = 20) or a non-training group (n = 19), and 19 normal controls. INTERVENTION...

There is strong evidence that the renal medullary circulation plays a key role in long-term blood pressure control. This, and evidence implicating sympathetic overactivity in development of hypertension, provides the need for understanding how sympathetic nerves affect medullary blood flow (MBF). The precise vascular elements that regulate MBF under physiological conditions are unknown, but lik...