Understanding how natural populations adapt to their local environments is a major research theme for ecological genomics. This endeavour begins by sleuthing for shared genetic similarities among unrelated natural populations sharing adaptive traits to documented selective pressures. When the selective pressures have low dimensionality, and the genetic response is localized to a few genes of ma...

It is generally accepted that the hatching of mouse blastocysts is accompanied by regional dissolution of the zona pellucida by a trypsin-like proteinase synthesized in trophectoderm cells (Perona and Wassarman, 1986; Hogan et al., 1994), and trophectoderm cells protrude from the dissolved hole of the zona pellucida (Orsini and McLaren, 1967; McLaren, 1970; Niimura and Fujii, 1997). Then a slit...

VERA P. KRYMSKAYA,1 RAYMOND B. PENN,2 MICHAEL J. ORSINI,2 PAMELA H. SCOTT,3 ROBIN J. PLEVIN,3 TREVOR R. WALKER,4 ANDREW J. ESZTERHAS,1 YASSINE AMRANI,1 EDWIN R. CHILVERS,4 AND REYNOLD A. PANETTIERI, JR.1 1Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104-4283; 2Department of Pharmacology, Jefferson Cancer Institute, Thoma...

The Role of Mathematical Modeling and Genetic Engineering for the Microalgae Based Technology Alessandro Concas*, Cristina Costelli, Veronica Malavasi, Massimiliano Orsini, Roberto Cusano, Andrea Angius, Massimo Pisu, Giacomo Cao a Center for Advanced Studies, Research and Development in Sardinia (CRS4), Loc. Piscina Manna, Building 1, 09010 Pula (CA), Italy b Interdepartmental Center of Enviro...