BACKGROUND The ventilatory capacity of the respiratory neuromuscular system can be studied with the hypercapnia test. OBJECTIVE To determine whether decreased response to the hypercapnia test is associated with failure to pass a spontaneous breathing trial (SBT) or extubation failure. METHODS We studied 103 intubated patients ready for SBT. We used a hypercapnia test in which we approximate...

BACKGROUND Spontaneous breathing trials (SBTs) and daily sedation interruptions (DSIs) reduce both the duration of mechanical ventilation and ICU length of stay (LOS). The impact of these practices in patients with ARDS has not previously been reported. We examined whether implementation of SBT/DSI protocols reduce duration of mechanical ventilation and ICU LOS in a retrospective group of subje...

BACKGROUND AND AIM Studies on weaning strategies have yielded conflicting results regarding the superiority of different methods. The aim of this RCT was to compare the efficacy of gradual pressure support (PS) reduction without an initial spontaneous breathing trial (SBT) with PS-supported SBT. METHODS Patients mechanically ventilated for >24h were randomized to weaning by gradual reduction ...

BACKGROUND The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain. METHODS We searched MEDLINE, EMBASE, CENTRAL, CINAHL, Evidence-Based Medicine Reviews, Ovid Health Star, proceedings of five conferences (1990-2016), and reference lists for randomized trials comparing SBT techniques in intubated adults ...

OBJECTIVE Despite the use of spontaneous breathing trial (SBT), predicting weaning success remains a major clinical challenge. Because cardiovascular dysfunction could be a major underlying mechanism of weaning failure, we evaluated the role of the levels of B-type natriuretic peptide (BNP), a marker for cardiovascular function, in patients who passed a 2-hr SBT. DESIGN, SETTING, AND PATIENTS...

Scheduled block time (SBT) setting is a crucial part in airlines’ scheduling. Interviews with the airline and relevant work in ground transportation have shown that SBT and the historical block time distribution have a close relationship. A better understanding of this relationship is a major goal for the FAA and the airlines because the benefits includes less cost, more efficient operations an...

The main aim of this study was to evaluate the therapeutic efficacy of an oil-in-water nanoemulsion formulation encapsulating DHA-SBT-1214, a novel omega-3 fatty acid conjugated taxoid prodrug, against prostate cancer stem cells. Nanoemulsions of DHA-SBT-1214 (NE-DHA-SBT-1214) were prepared and characterized. In vitro delivery efficiency and cytotoxicity of NE-DHA-SBT-1214 was compared with sol...

Seabuckthorn (SBT) seed oil is a rich source of unsaturated fatty acids, phytosterols, carotenoids and flavonoids, which are known to have significant anti-atherogenic and cardioprotective activity. The anti-atherogenic activity of supercritical CO(2) extracted SBT seed oil was evaluated in white albino rabbits fed on high cholesterol diet for 60 days. The study was performed on 20 male healthy...

BACKGROUND The aim of this study was to explore whether serum baseline tryptase (sBT) levels might be a useful marker not only for the accurate diagnosis of childhood asthma, but also for the prediction of disease severity. METHODS A total of 114 asthmatic children were enrolled in this study, 36 of whom had mild intermittent asthma, 38 had mild persistent asthma, and 40 had moderate to sever...

We introduce the Stupid Barrier Tricks (SBT) library for on-line debugging and performance monitoring of sharedmemory parallel programs. Single-program-multiple-data (SPMD) programs often use barriers to synchronize threads of execution and to delimit the start and end of different phases of computation. Through the novel (and simple) named barriers construct, dynamic performance warnings, and ...