Membrane transporter proteins may influence the sensitivity of cancer cells to anticancer drugs that can be recognized as substrates. The purpose of this study was to identify proteins that play a key role in the drug sensitivity of stomach and breast cancer cell lines by measuring the absolute protein expression levels of multiple transporters and other membrane proteins and examining their co...

Tumor associated macrophages (TAMs) can modify the tumor microenvironment to create a pro-tumor niche. Manipulation of the TAM phenotype is a novel, potential therapeutic approach to engage anticancer immunity. siRNA is a molecular tool for knockdown of specific mRNAs that is tunable in both strength and duration. The use of siRNA to reprogram TAMs to adopt an immunogenic, anti-tumor phenotype ...

This document suggests an X.500 Directory Schema, or Naming Architecture, for use in the COSINE and Internet X.500 pilots. The schema is independent of any specific implementation. As well as indicating support for the standard object classes and attributes, a large number of generally useful object classes and attributes are also defined. An appendix to this document includes a machine process...

The Internet is rapidly becoming the communications infrastructure. With its advantages of speed, availability, and `different time, different place' mode of communication, it can be successfully harnessed to accomplish tasks that previously required face-to-face meetings. Such meetings can consume large travel budgets and staff time, and therefore alternative mechanisms that achieve the same r...

هیدروفرمینگ لوله به‌طور گسترده، در تولید قطعات ساختاری اتومبیل استفاده می‌شود. یکی از خصوصیات تولید‌شده با این فرایند، نسبت استحکام به وزن بالا می‌باشد. لولۀ فشار پایین، روش‌های پیشنهاد‌شده برای حل مشکلات قبیل نیاز بالای سیال و آب‌بندی روش انجام پایین لوله، شبیه فشردن جسم جامد است آن برخلاف بالا، قالب بالایی طول فرایند ثابت نبوده هم‌زمان اعمال داخلی حرکت کرده را تحت قرار می‌دهد. مقاله، لوله‌های...

Département de Santé Publique, Unité de Recherche sur les Politiques et Systèmes de Santé, Centre Muraz, 2054 Avenue Mamadou Konaté, 01 BP 390 Bobo-Dioulasso, Burkina Faso Agence de Formation, de Recherche et d’Expertise en Santé pour l’Afrique (AFRICSanté), 773 Rue Guillaume Ouédraogo 01 BP 298 Bobo-Dioulasso, Burkina Faso Department of Community Medicine, University of Oslo, Post Box 1130 Bli...

In the words of Lord Kelvin, “if you cannot measure it, you cannot improve it”. One of the longlasting successes of the Top 500 list is sustained, community-wide floating point performance improvement. Emerging large-data problems, either resulting from measured real-world phenomena or as further processing of data generated by simulation, have radically different performance characteristics an...