نتایج جستجو برای: شکل دهنده پرتو gsc

تعداد نتایج: 106376  

Journal: :Proceedings of the International Astronomical Union 2007

Journal: :Mechanisms of Development 1998
José António Belo Luc Leyns Gen Yamada Eddy M. De Robertis

Gsc-1 expression marks cells with Spemann organizer, or axis-inducing, activity in the vertebrate gastrula. Gsc-1 knockouts, however, did not display phenotypes related to the early phase of expression. In this paper, additional phenotypes for the Gsc-1 mouse mutant are presented. Examination of the base of the cranium in the dorsal view revealed fusions and deletions in the midline of the prec...

2008
Ting Xie

1. The anatomically simplest GSC niche in C. elegans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2. The first structurally and functionally defined GSC niche in the Drosophila ovary . . . . . . . . . . . . . . . . . . . . 4 3. The structurally and mechanistically well-studied GSC niche in the Drosophila testis . . . . . . . . . . . . . . . . . 6 4...

2017
Bärbel Ulmer Melanie Tingler Sabrina Kurz Markus Maerker Philipp Andre Dina Mönch Marina Campione Kirsten Deißler Mark Lewandoski Thomas Thumberger Axel Schweickert Abraham Fainsod Herbert Steinbeißer Martin Blum

Goosecoid (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond. While functions have been assigned during later embryogenesis, the role of Gsc in the organizer has remained enigmatic. Using conditional gain-of-function approaches in Xenopus and mouse to maintain Gsc expression in the organizer and along the axial midline, neural tube closure defects (NTDs) arose and ...

2015
Dror Freirich

2012
Mohammad Lalmoddin Mollah Dong Ki Park Hye-Jin Park

Cordyceps militaris (CM) is an insect-borne fungus that has been used in traditional Chinese medicine because of its wide range of pharmacological activities. In this paper, we studied CM grown on germinated soybean (GSC) and investigated the possible mechanisms underlying antiproliferative effect of GSC on HT-29 human colon cancer cells. In comparison with CM extracts and germinated soybean (G...

Journal: :Cancer research 2014
Andreas Herrmann Gregory Cherryholmes Anne Schroeder Jillian Phallen Darya Alizadeh Hong Xin Tianyi Wang Heehyoung Lee Christoph Lahtz Piotr Swiderski Brian Armstrong Claudia Kowolik Gary L Gallia Michael Lim Christine Brown Behnam Badie Stephen Forman Marcin Kortylewski Richard Jove Hua Yu

Understanding supports for cancer stem-like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the Toll-like receptor TLR9 is elevated in glioma stem-like cells (GSC) in which it contributes to glioma growth. TLR9 overexpression is regulated by STAT3, which is required for GSC maintenance. Stimulation of TLR9 with a CpG ligand (CpG ODN) promot...

Journal: :Mechanisms of Development 2007
Samara L. Lewis Poh-Lynn Khoo R. Andrea De Young Heidi Bildsoe Maki Wakamiya Richard R. Behringer Mahua Mukhopadhyay Heiner Westphal Patrick P.L. Tam

Mouse embryos lacking Gsc and Dkk1 function display severe deficiencies in craniofacial structures which are not found in either Dkk1 homozygous null or Gsc homozygous null mutant embryos. Loss of Gsc has a dosage-related effect on the severity of head truncation phenotype in Dkk1 heterozygous embryos. The synergistic effect of these mutations in enhancing head truncation provides direct eviden...

Journal: :Development 1995
J A Rivera-Pérez M Mallo M Gendron-Maguire T Gridley R R Behringer

Goosecoid (gsc) is an evolutionarily conserved homeobox gene expressed in the gastrula organizer region of a variety of vertebrate embryos, including zebrafish, Xenopus, chicken and mouse. To understand the role of gsc during mouse embryogenesis, we generated gsc-null mice by gene targeting in embryonic stem cells. Surprisingly, gsc-null embryos gastrulated and formed the primary body axes; gsc...

2009
Dawn Field Peter Sterk Nikos Kyrpides Renzo Kottmann Frank Oliver Glöckner Lynette Hirschman George M. Garrity John Wooley Paul Gilna

This report summarizes the proceedings of the 6th and 7th workshops of the Genomic Standards Consortium (GSC), held back-to-back in 2008. GSC 6 focused on furthering the activities of GSC working groups, GSC 7 focused on outreach to the wider community. GSC 6 was held October 10-14, 2008 at the European Bioinformatics Institute, Cambridge, United Kingdom and included a two-day workshop focused ...

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