نتایج جستجو برای: شبکه rtk
تعداد نتایج: 37584 فیلتر نتایج به سال:
Drosophila Corkscrew protein and its vertebrate ortholog SHP-2 (now known as Ptpn11) positively modulate receptor tyrosine kinase (RTK) signaling during development, but how these tyrosine phosphatases promote tyrosine kinase signaling is not well understood. Sprouty proteins are tyrosine-phosphorylated RTK feedback inhibitors, but their regulation and mechanism of action are also poorly unders...
Cancer cells employ multiple mechanisms to evade tightly regulated cellular processes such as proliferation, apoptosis, and senescence. Systems-wide analyses of tumors have recently identified receptor tyrosine kinase (RTK) coactivation as an important mechanism by which cancer cells achieve chemoresistance. This mini-review discusses our current understanding of the complex and dynamic process...
Receptor tyrosine kinase (RTK) signals regulate the specification of a varied array of tissue types by utilizing distinct modules of proteins to elicit diverse effects. The RSK proteins are part of the RTK signal transduction pathway and are thought to relay these signals by acting downstream of extracellular signal-regulated kinase (ERK). In this study we report the identification of ribosomal...
در میان شبکۀ معابر شهری، راه‌های اضطراری امدادرسانی حین زلزله، به‌ویژه مرحلۀ پاسخ به بحران، نقش مهمی ایفا می‌کنند. حفظ عملکرد این شبکه از معابر، ساعات اولیۀ پس اهمیت بسزایی دارد. محافظت و مقاوم‌سازی اجزای آسیب‌پذیر شبکه، به‌خصوص پل‌ها، پیش وقوع تأثیر شایان توجهی کاهش خسارات آسیب‌ها اغلب اوقات تمامی آسیب‌پذیر، به‌دلیل محدودیت بودجه، عملاً ناممکن است. ایجاب می‌کند که با شناسایی دقیق گزینه‌های ابتد...
RTK/Ras/MAPK signaling pathways play key functions in metazoan development, but how they control expression of downstream genes is not well understood. In Drosophila, it is generally assumed that most transcriptional responses to RTK signal activation depend on binding of Ets-family proteins to specific cis-acting sites in target enhancers. Here, we show that several Drosophila RTK pathways con...
GNSS community has developed a series of GPS-based techniques for clock measurements and comparisons including time dissemination with the standard GPS point positioning method, clock synchronization using the codebased differential GPS positioning technique and using precise point positioning (PPP) for clock comparison. In the mean time, significant advances have been made towards real time ki...
Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using fibroblast growth factor receptor (FGFR) inhibition in endometrial cancer cells, we identify an Akt-driven...
A limited number of whole-cell assays allow monitoring of receptor tyrosine kinase (RTK) activity in a signaling pathway-specific manner. We present the general use of the bioluminescence resonance energy transfer (BRET) technology to quantitatively study the pharmacology and signaling properties of the receptor tyrosine kinase (RTK) superfamily. RTK BRET-2 assays monitor, in living cells, the ...
The induction of protein tyrosine kinase signaling pathways is a principal mechanism for promoting cellular activation. Biochemical and genetic analyses have implicated the multi-adaptor proto-oncogene protein Cbl as a key negative regulator of activated protein tyrosine kinases. By inhibiting the function of Cbl as a multi-domain adaptor protein, through expression of a truncated form (480-Cbl...
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