Phase 1 trials of molecularly targeted agents (MTA) often do not use toxicity data beyond the first cycle of treatment to determine a recommended phase 2 dose (RP2D). We investigated the potential utility of longitudinal relative dose intensity (RDI) that may be a better new way of determining a more accurate RP2D as a lower dose that is presumably more tolerable over the long term without comp...

OBJECTIVE To determine the association between body position and obstructive events during sleep as determined by polysomnography (PSG) in very young children (age, < or = 3 years) with obstructive sleep apnea syndrome. DESIGN Retrospective chart review. SUBJECTS Children aged 3 years and younger who underwent PSG to evaluate obstructive sleep apnea and subsequently underwent adenotonsillec...

PURPOSE To evaluate the impact on survival of the relative dose intensity (RDI) achieved in patients with early breast cancer receiving anthracycline plus taxane-based chemotherapy in the adjuvant setting. PATIENTS AND METHODS Patients with early breast cancer diagnosed from January 1999 through December 2006 were included. Dose intensity was evaluated according to the number of delayed cycle...

DLBCL is an aggressive lymphoma treated with R-CHOP. Recently, attempts have been made to improve the outcome by increasing both dose-density and intensity but there have been no benefits in terms of survival. When treating malignancies RDI is important to consider but there is little published information on DLBCL. The purpose of this study was to analyze the differential prognostic impact of ...

THE MOST COMMONLY USED INDICATOR OF SLEEP DISORDERED BREATHING (SDB) SEVERITY IS THE RESPIRATORY DISTURBANCE INDEX (RDI), WHICH IS SYNONYMOUS WITH THE APNEA HYPOPNEA INDEX (AHI) IN MANY REPORTS. The RDI is the total number of apneas and hypopneas per hour of sleep. In clinical populations, the RDI is used to define the presence of SDB and thus identify individuals who require treatment.1,2 In a...

OBJECTIVE To examine links between obstructive sleep apnea (OSA), insulin resistance, and dyslipidemia. STUDY DESIGN Obese (body mass index [BMI] >95th percentile for age and gender) children who snored (n = 62, 46 males, age 10.89 [5-16 years] underwent polysomnography and metabolic studies. RESULTS Respiratory disturbance index (RDI) was 9.23 (0-95), with 23 children (39%) recommended for...