background and objective: esophageal cancer especially squamous cell carcinoma (scc) is one of the most common gastro intestinal malignancies in north part of iran (khorasan). the standard treatment for esophageal cancer is surgical resection, but its outcome remains poor. then, the oncologists try to treat this cancer with sandwich protocols especially neo-adjuvant chemo-radiotherapy. several ...

This paper is on the normal approximation of singular subspaces when noise matrix has i.i.d. entries. Our contributions are three-fold. First, we derive an explicit representation formula empirical spectral projectors. The neat and holds for deterministic perturbations. Second, calculate expected projection distance between true subspaces. method allows obtaining arbitrary k-th order distance. ...

We reconsider the semileptonic decays of B→D1(′)lν¯l. The previous theoretical calculations predict a significantly smaller rate for decay B to D1′(Jl=12) compared with that D1(Jl=32), which is not consistent current experimental data. This conflict known as so-called ‘12 vs. 32 puzzle’. In this work, we propose simple scheme fix problem, where suppose strong eigenstates D1(′) do coincide eigen...

This work mainly focuses to unveil the optical features of a black hole. For this objective, we utilize metric-affine hole geometry, including dilation, spin, and shear charge. The Lagrangian coefficients f1 d1 are main parameters that differentiate solutions by d1=±8f1, where f1<0. Based on these parameters, carry out in two cases, i.e., d1=8f1,&d1=−8f1. We forecast detailed impact charges pro...

Background: Zearalenone (ZEA) is known as a nonsteroidal oestrogenic mycotoxin produced by different species of Fusarium fungi. ZEA is known for its competitive effects with the natural 17-β estradiol to bind with the specific binding sites of the estrogen receptors (Ers). On the other hand, the cyclin family (especially cyclin D1) and E2F1 genes are the checkpoint genes involved in cell cycle....

Ultrapotent chemogenetics, including the chloride-permeable inhibitory PSAM 4 -GlyR receptor, were recently proposed as a powerful strategy to selectively control neuronal activity in awake, behaving animals. We aimed validate function of dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) ventral striatum. Activation with uPSEM 792 ligand enhanced rather than suppressed D1-MSNs vivo...

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...