Calculations of properties materials require performing numerical integrals over the Brillouin zone (BZ). Integration points in density functional theory codes are uniformly spread BZ (despite integration error being concentrated small regions BZ) and preserve symmetry to improve computational efficiency. an irreducible (IBZ), a rotationally distinct region BZ, do not have crystal for greater T...

Long-term (mean, 8 years) users of benzodiazepines (BZs) were administered a small battery of cognitive tests on three occasions (before BZ taper, and 5 and 12 weeks post taper) as part of their BZ discontinuation program. Ninety-six patients had 5-week and 77 patients had 12-week data. For taper successes, BZ-free status was confirmed by weekly BZ plasma level determinations. Age and education...

BACKGROUND: When measuring skin blood perfusion with laser-Doppler methods in a limb, a non-zero perfusion is sometimes registered even when the arterial inflow to, and venous outflow from the site of measurement is arrested using proximal cuff compression pressures well in excess of systolic blood pressure. This residual signal, known as the biological zero (BZ)1-7, is present to some extent w...

Chronic chagasic cardiomyopathy (CCC) progresses with parasite persistence, fibrosis, and electrical alterations associated with an unbalanced immune response such as high plasma levels of tumor necrosis factor (TNF) and nitric oxide (NO). Presently, the available treatments only mitigate the symptoms of CCC. To improve CCC prognosis, we interfered with the parasite load and unbalanced immune r...

Iron chelators have been employed in various studies aimed at evaluating the relationship between the iron status of the host and the development of infection. In the present study, the effects of benznidazole (BZ) therapy in combination with the iron chelator desferrioxamine (DFO) on the development of infection in mice inoculated with Trypanosoma cruzi Y strain have been investigated. Infecte...

The histone deacetylase inhibitor SAHA enhances cell death stimulated by the proteasome inhibitor bortezomib (BZ) by disrupting BZ-induced aggresome formation. Here we report that Myc regulates the sensitivity of multiple myeloma (MM) cells to BZ + SAHA-induced cell death. In MM cells, Myc expression directly correlated with intracellular ER content, protein synthesis rates, the percentage of a...

[3H8]Thromboxane Bz was biosynthesized and infused into an unanesthetized monkey. Several urinary metabolites were isolated and their structures elucidated using gas chromatography-mass spectrometry. In addition to the major urinary metabolite, dinor-thromboxane Bz, a series of metabolites resulting from dehydrogenation of the alcohol group at C-11 were identified: 11-dehydro-thromboxane Bz, 11...

Bortezomib (BZ), a first line 26S proteasome inhibitor, induces a potent cytocidal effect with caspase-3 activation in multiple myeloma (MM) cell lines. Since IκBα is a substrate of the proteasome, the initial rationale for using BZ in MM has been to inhibit NF-κB. However, BZ rather activated NF-κB activity in U266 cells. BZ induces autophagy as well as endoplasmic reticulum (ER) stress in var...

Ternary mixtures of Bromocresol Green (BCGH), Benzethonium Chloride (BZ(+)Cl(-)), and Quinine (Q) in dichloromethane (CH(2)Cl(2) for ratios 1:>/=1:>/=1 (BCGH(2):BZ(+)Cl(-):Q) generate species BCGH(-)BZ(+), BZ(+)BCG(-)-H-Q) and BCG(2-) (BZ(+))(2) in chemical equilibrium; whose thermodynamic parameters are determined. A new method to study ternary mixtures in a non-polar solvent has been given an...