Numerous targeted treatments for atopic dermatitis (AD) are currently under investigation in clinical trials. Comparability of the efficacy new drugs is therefore becoming more important. Serum biomarkers may offer an objective outcome measure disease severity AD. A combination serum TARC, IL-22, and sIL-2R as a signature (predicted EASI) measurement tool AD patients treated with topical steroi...

The behavior of the classic algorithm for blind source separation is reviewed for a fixed step-size. The inherent contradiction of the classic equivariant adaptive source separation via independence algorithm (EASI) make it very difficult to balance convergence speed and the steady-state misadjustment error. In this paper, In response to the above contradiction, a Fuzzy Neural Network(FNN)-base...

| Source separation consists in recovering a set of independent signals when only mixtures with unknown coeecients are observed. This paper introduces a class of adaptive algorithms for source separation which implements an adaptive version of equivariant estimation and is henceforth called EASI (Equivariant Adaptive Separation via Independence). The EASI algorithms are based on the idea of ser...

Baricitinib, an oral, selective, and reversible Janus kinase 1/2 inhibitor, has been used for moderate-to-severe AD in patients aged >15 years Japan from December 2020. In this study, we analyzed 14 Japanese adult with atopic dermatitis who were treated baricitinib at Gunma University Hospital. We present our real-world data combination hematological improvement rates, the relationship between ...

Using a cellulose dialysis membrane and aqueous solutions of common drugs as a proof-of-principle example, we demonstrate that solid but permeable and flexible membranes can be used as interfaces for the direct analysis of solution constituents via easy ambient sonic-spray ionization mass spectrometry. This new combination of MS techniques, herein termed EASI-MIMS, promotes droplet pick up of t...

The natural history of chronic obstructive pulmonary disease (COPD) is still not well understood. Traditionally believed to be a self-inflicted disease by smoking, now we know that not all smokers develop COPD, that other inhaled pollutants different from cigarette smoke can also cause it, and that abnormal lung development can also lead to COPD in adulthood. Likewise, the inflammatory response...