AN INVESTIGATION INTO THE PHYSIOLOGICAL ROLE OFANNEXIN A11 A. Tomas and S.E. MossDivision of Cell Biology, Institute of Ophthalmology, University College London, London (UK) Annexin A11 is a calcium-dependent phospholipid-binding protein that interacts in vitro with the EF-hand protein, Calcyclin. It is broadly distributed and has the longestN-terminal domain (197 aa) of all known a...

• First, the lower bidiagonal matrix A11 with nonzero bidiagonal elements has full column rank and its singular values are simple. Consequently, any zero singular values or repeats that A has must appear in A22. • Second, A11 has minimal dimensions, and A22 has maximal dimensions, over all orthogonal transformations giving the block structure in (2), without any additional assumptions on the st...

We prove that if A ⊂ Fq\{0} with |A| > Cq 5 6 , then |R(A) ·R(A)| ≥ C′q3, where R(A) = {( a11 a12 a21 a22 ) ∈ SL2(Fq) : a11, a12, a21 ∈ A } . The proof relies on a result, previously established by D. Hart and the author ([3]) which implies that if |A| is much larger than q 3 4 then |{(a11, a12, a21, a22) ∈ A×A×A×A : a11a22 − a12a21 = 1}| = |A|4q−1(1 + o(1)).

CD40-positive dendritic cells (DCs) are stimulated with CD40 ligand (CD40L) and subsequently secrete a number of cytokines including interleukin (IL)-23, which is involved in cell-mediated immune responses. Expression of CD40 ligand (CD40L) on tumors can activate host immune systems and produce antitumor effects against the tumors. We examined a possible mechanism of the antitumor responses: tu...

Citations in Economics: Measurement, Uses and Impacts* I describe and compare sources of data on citations in economics and the statistics that can be constructed from them. Constructing data sets of the post-publication citation histories of articles published in the “Top 5” journals in the 1970s and the 2000s, I examine distributions and life cycles of citations, compare citation histories of...

The Net Present Value maximizing model has a respectable ancestry and is considered by most scholars a theoretically sound decision model. In real-life applications, decision makers use the NPV rule, but apply a subjectively determined hurdle rate, as opposed to the “correct” opportunity cost of capital. According to a heuristics-and-biases-program approach, this implies that the hurdle-rate ru...

Although the external influence of scholars has usually been approximated by publication and citation count, the array of scholarly activities is far more extensive. Today, new technologies, in particular Internet search engines, allow more accurate measurement of scholars’ influence on societal discourse. Hence, in this article, we analyse the relation between the internal and external influen...

An identity links the rate of economic growth, the speed of poverty reduction and changes in the distribution of income during some time period in a given country. A few authors used that identity to understand the causes for observed changes in poverty and to identify the exact role of economic growth in poverty reduction. Yet, many empirical cross-country studies of the relationship between g...

A whole body physiologically based pharmacokinetic (PBPK) model was applied to investigate absorption, distribution, and physiologic variations on pharmacokinetics of imatinib in human body. Previously published pharmacokinetic data of the drug after intravenous (i.v.) infusion and oral administration were simulated by the PBPK model. Oral dose absorption kinetics were analyzed by adopting a co...