Renal cell carcinoma (RCC) is one of most fatal cancers. In most patients it is resistant to chemotherapy. Ferula gummosa gum, Scutellaria lindbergii, Kelussia odoratissima, and Artemisia kopetdaghensis are herbs about which there are some cytotoxic activity reports. In this study, cytotoxic and apoptotic activity of these four extracts on RCC cell line (ACHN) were evaluated and compared (ACHN)...

سابقه و هدف: سلامت خاک از مولفه ‏های اصلی در دستیابی به سامانه ‏‏های کشاورزی پایدار بوده که شدت تحت تاثیر عملیات زراعی مانند خاکورزی قرار می ‏گیرد. را توان با استفاده پارامترهای فیزیکی، شیمیایی بیولوژیکی قالب الگوریتم‏ های مشخص کمّی کرد. نتیجه، بررسی وضعیت کیفی باروری مدیریتی مختلف زمین جهت استقرار مناسب برای تولید بهینه نظام‌های امری ضروری می‏ باشد. چارچوب ارزیابی مدیریت SMAF 1 عنوان ابزاری قدر...

One of the primary factors for generating heating and cooling loads in apartment houses is infiltration. However, evaluation method infiltration rates has not been well established Korea. The existing measures air change per hour a house at 50 Pa (ACH50) divides it by leakage–infiltration ratio, N = 20, as suggested Lawrence Berkeley National Laboratory (LBL). In this study, to evaluate average...

In this report, we present a characterization of the cell-specific expres slon of two human cytochrome P450 genes, CYPIAJ and CYP1BJ, by 2,3,7,S-tetrachlorodibenzo-p-dloxin (TCDD). The TCDD-dependent In ductionof CYPJAJhas beenstudiedextensivelyand servesas the proto type response for a TCDD-signaling pathway initiated by the reversible binding of TCDD to an Intracellular receptor [designated t...

We investigated whether Ukrain modulates the malignant phenotype of clear cell renal cell carcinoma (ccRCC) cells Caki-1, Caki-2, and ACHN treated with four doses (5, 10, 20, and 40 μmol/l) for 24 and 48 h. The epithelial-to-mesenchymal transition markers E-cadherin, β-catenin, and vimentin were analyzed by immunofluorescence as well as actin and tubulin; matrix metalloproteinase-2 and matrix m...

PURPOSE 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes [methylene-substituted diindolylmethanes (C-DIM)] containing p-trifluoromethyl, p-t-butyl, and p-phenyl substituents activate peroxisome proliferator-activated receptor gamma (PPARgamma) and inhibit growth of several different cancer cell lines through receptor-dependent and receptor-independent pathways. The purpose of this study is t...

Anti-Fas monoclonal antibody (mAb) kills Fas-expressing cells by apoptosis. Several anticancer agents also mediate apoptosis and may share common intracellular pathways leading to apoptosis with Fas. Thus, we reasoned that combination treatment of drug-resistant cells with anti-Fas mAb and drugs might overcome their resistance. We investigated whether anticancer agents enhance Fas-mediated apop...

ACHN-490 is an aminoglycoside with activity against multidrug-resistant pathogens, including those resistant to currently used aminoglycosides. Two randomized, double-blind, placebo-controlled clinical studies investigated the pharmacokinetics (PK), safety, and tolerability of ACHN-490 injection in healthy subjects. Study 1 used a parallel-group design with escalating single (SD) and multiple d...

Anti-Fas monoclonal antibody (mAb) kills Fas-expressing cells by apoptosis. Several anticancer agents also mediate apoptosis and may share common intracellular pathways leading to apoptosis with Fas. Thus, we reasoned that combination treatment of drug-resistant cells with anti-Fas mAb and drugs might overcome their resistance. We investigated whether anticancer agents enhance Fas-mediated apop...

Resistance of human renal cell carcinoma (RCC) and melanoma to the apoptosis-inducing effects of IFNs was postulated to result from epigenetic silencing of genes by DNA methylation, a common feature of human cancers. To reverse silencing, 5-AZA-deoxycytidine (5-AZA-dC) or selective depletion of DNA methyltransferase 1 (DNMT1) by phosphorothioate oligonucleotide antisense (DNMT1 AS) were employe...