PURPOSE To determine the MTD, dose-limiting toxicities (DLT), pharmacokinetics, and biologic effects of cixutumumab administered in combination with temsirolimus to children with refractory solid tumors. EXPERIMENTAL DESIGN Cixutumumab and temsirolimus were administered intravenously once every 7 days in 28-day cycles. Pharmacokinetic and biology studies, including assessment of mTOR downstre...

It is shown that if R and S are Morita equivalent rings then R has weakly stable range 1 (written as wsr(R) = 1) if and only if S has. Let T be the ring of a Morita context (R,S,M,N,ψ, φ) with zero pairings. If wsr(R) = wsr(S) = 1, we prove that T is a weakly stable ring. A ring R is said to have weakly stable range one if aR + bR = R implies that there exists a y ∈ R such that a + by ∈ R is ri...

The fabrication of novel uranyl (UO(2)(2+)) binding protein based sensors is reported. The new biosensor responds to picomolar levels of aqueous uranyl ions within minutes using Lysinibacillus sphaericus JG-A12 S-layer protein tethered to gold electrodes. In comparison to traditional self assembled monolayer based biosensors the porous bioconjugated layer gave greater stability, longer electrod...

Immune checkpoint inhibitors promote T cell-mediated killing of cancer cells; however, only a subset of patients benefit from the treatment. A possible reason for this limitation may be that the tumor microenvironment (TME) is immune privileged, which may exclude cytotoxic T cells from the vicinity of cancer cells. The chemokine CXCL12 is key to the TME-driven immune suppression. In this study,...

Al Introduction A2 Acknowledgments A2 Gold as a store of wealth the uses of gold A2 How much gold? A2 Factors influencing the price and production of gold A3 The role of gold in world monetary systems A6 Where gold comes from A6 Scope of this series, and conventions used A7 References cited A8 Geochemistry of gold in hydrothermal deposits Abstract A9 Introduction A9 Nature and source of solutio...

Uncoupling protein-2 (UCP2) regulates insulin secretion and may play an important role in linking obesity to type 2 diabetes (T2D). Previous studies of the role of the UCP2 promoter -866G/A single nucleotide polymorphisms (SNP) in T2D have given opposite results. We tested the distribution of the -866G/A SNP in 746 T2D patients and 327 healthy unrelated Caucasians from Italy. We also tested for...

PURPOSE To determine the effect of inhibition of insulin-like growth factor-IR (IGF-IR) signaling with an antibody to the IGF-IR, A12, in conjunction with androgen withdrawal on prostate cancer progression in a human prostate xenograft model, LuCaP 35. EXPERIMENTAL DESIGN LuCaP 35 was implanted s.c. in severe combined immunodeficient mice. At the time of castration, mice were randomized to on...

In this paper we construct a moduli space for marked rational elliptic surfaces of index two as non-complete toric variety dimension nine. We also compactifications space, which are obtained quotients A12 by an action Gm3.

OBJECTIVE Activation of the peroxisome proliferator-activated receptor-gamma (PPARgamma) improves insulin sensitivity and exerts antiatherogenic effects. A common alanine for proline substitution at codon 12 in the PPARG2 gene is related to lower receptor activity. Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart...