Herpes simplex virus type 1 (HSV-1) encodes 11 envelope glycoproteins, of which glycoprotein G-1 (gG-1) induces a type-specific antibody response. Variability of the gG-1 gene among wild-type strains may be a factor of importance for a reliable serodiagnosis and typing of HSV-1 isolates. Here, we used a gG-1 type-specific monoclonal antibody (MAb) to screen for mutations in the immunodominant r...

background bipolar disorder is a biological brain disorder which is associated with debilitating fluctuation in mood and adverse effects on patients, their families and society. the importance of genetics and its role in bipolar disorder is a controversial issue to discuss. evidence indicates a relation between the risk of bipolar disorder and specific genes. amongst the genes whose role has be...

Given a set P of n points in the plane, the order-k Gabriel graph on P , denoted by k-GG, has an edge between two points p and q if and only if the closed disk with diameter pq contains at most k points of P , excluding p and q. We study matching problems in k-GG graphs. We show that a Euclidean bottleneck matching of P is contained in 10-GG, but 8-GG may not have any Euclidean bottleneck match...

Fruit size regulation was studied in the apple cultivar 'Gala' and a large fruit size spontaneous mutant of 'Gala', 'Grand Gala' (GG). GG fruits were 15% larger in diameter and 38% heavier than 'Gala' fruits, largely due to an increase in size of the fruit cortex. The mutation in GG altered growth prior to fruit set and during fruit development. Prior to fruit set, the carpel/floral-tube size w...

The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD). GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant...

We present sub-arcsecond images of the mm dust emission and 13CO J=2–1 line emission in the young quadruple system GG Tau. These observations unambiguously resolve the circumbinary disk of the close (∼ 0.3′′) binary system into two distinct components: an extremely dense, sharp-edged ring, surrounded by an extended disk. Continuum emission is also detected from the center of this structure; it ...

The differences in efficacy and molecular mechanisms of platinum based anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) have been hypothesized to be in part due to the differential binding affinity of cellular and damage recognition proteins to CP and OX adducts formed on adjacent guanines in genomic DNA. HMGB1a in particular exhibits higher binding affinity to CP-GG adducts, and the exten...

A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...