Staphylococcus aureus virulence has been associated with the production of phenol soluble modulins (PSM). PSM are known to activate, attract and lyse neutrophils. However, the functional characterizations were generally performed in the absence of human serum. Here, we demonstrate that human serum can inhibit all the previously-described activities of PSM. We observed that serum can fully block...

The phenol-soluble modulin PSM-mec is the only known staphylococcal toxin that is encoded on a mobile antibiotic resistance determinant, namely the staphylococcal cassette chromosome (SCC) element mec encoding resistance to methicillin. Here we show that the psm-mec gene is found frequently among methicillin-resistant Staphylococcus aureus (MRSA) strains of SCCmec types II, III, and VIII, and i...

OBJECTIVE To assess whether light drinking in pregnancy is linked to unfavourable developmental outcomes in children. DESIGN Prospective population-based cohort. SETTING UK. POPULATION Ten thousand five hundred and thirty-four 7-year-olds. METHODS Quasi-experimental using propensity score matching (PSM) to compare children born to light (up to 2 units per week) and non-drinkers. MAIN ...

We propose a modified power-saving mechanism (PSM) that reversely applies the state transition of legacy LTE PSM by considering the attributes of network propagation delay. We analyze the PSM with respect to the energy consumption and the buffering delay, and characterize them as a simple energydelay tradeoff (EDT) curve according to the operational parameters. The resulting EDT curves clearly ...

This paper examines whether the relationship between transformational leadership and organisational citizenship behaviours is contingent on public service motivation (PSM). We propose that PSM may reduce followers’ reliance on the motivational behaviours of transformational leaders in public sector organisations. Using a sample of Mexican employees we tested this proposition with structural equ...

The intermolecular interactions in concentrated solutions of pig submaxillary mucin (PSM) and sheep submaxillary mucin (SSM) were studied by mechanical spectroscopy. PSM and SSM were purified from detectable protein and nucleic acid by equilibrium centrifugation in a CsCl density gradient. PSM and SSM isolated in the presence of proteinase inhibitors showed distinct differences from preparation...

To retrospectively verify the exact margin status and analyze the location and characteristics of positive surgical margins (PSM) in radical prostatectomy patients by a central pathology review based on the consensus conference 2009 updated margin criteria from the International Society of Urological Pathology (ISUP). Detailed PSM characteristics of 441 patients who underwent laparoscopic radic...

How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic changes during development of organogenesis-stage mouse embryos, focusing on the presomitic mesoderm (PSM). We measured glycolytic labeling kinetics from 13C...

We motivate the use of Problem-Solving Methods (PSM) in order to realize reusable knowledge models. The notion of PSM is extended to Frameworks of Problem Solving (FPS), thus giving PSM a larger generality and enable specialization or update of PSM during system development. An example of a FPS in the context of a project dealing with model-based diagnosis illustrates the approach. Finally, we ...

The cause of propriospinal myoclonus (PSM) is idiopathic. Cervical trauma, ischemic myelopathy secondary to a spinal dural arteriovenous fistula, syringomyelia, Lyme neuroborreliosis, human immunodeficiency virus central nervous system infection, and cervical disc herniation can be the cause of PSM, but lumbar herniated intervertebral disc (HIVD) induced PSM has not been reported. We describe a...