Cell lines derived from the sphingomyelinosis (gene symbol, spm) mouse were established from homozygous (spm/spm) and heterozygous (spm/+) embryos according to a rigid 3T3 transfer schedule. The SPM-3T3 cells derived from a homozygous embryo showed extensive accumulation of intracellular cholesterol, attenuated esterification of exogenously added cholesterol and increased de novo cholesterol sy...

BACKGROUND Neuroendocrine tumors (NET) are frequently associated with synchronous or metachronous secondary primary malignancies (SPM). The aim of this study was to report on 14 patients with NET and SPM from a series of 96 patients with NET. PATIENTS AND METHODS Fourteen patients with NET and synchronous or metachronous SPM were reviewed for primary site and characteristics of NET and associ...

AIM To explore the possibilities of feeding unconventional agro-industrial byproduct for livestock production. Sugarcane press-mud (SPM), is a byproduct derived from sugarcane industry, which is rich in protein as well as minerals. The effects of dietary inclusion of SPM at different levels on the carcass characteristics of lambs were evaluated. MATERIALS AND METHODS SPM was incorporated in c...

The objective of this research was to analyse whether ameliorating drought stress through exogenously applied spermine (Spm) was related to carbohydrate metabolism, dehydrins accumulation and the transcription of genes encoding dehydrins in two white clovers (drought-susceptible cv. 'Ladino' and drought-resistant cv. 'Haifa') under controlled drying conditions for 10 days. The results show that...

The gene encoding the metallo-beta-lactamase SPM-1 was cloned from a genomic library of Pseudomonas aeruginosa strain 48-1997 A. The insert carrying spm-1 possessed a GC content of 47%, indicating that it is of non-Pseudomonas origin. Upstream of spm-1 there is a small open reading frame (ORF), which is homologous to the LysR family of proteins (69% identity to the LysR protein from Salmonella ...

Maize Suppressor-mutator (Spm) transposable elements have been introduced into tobacco cells and a visual assay for Spm activity has been developed using a bacterial beta-glucuronidase gene. The Spm element is mobile in tobacco and can trans-activate excision of a transposition-defective Spm (dSpm) element either from a different site on the same transforming Ti plasmid or from a second plasmid...

Gray matter volumetry (i.e., atlas-based volumetry [1, 2]) and morphometry (i.e., voxel-based morphometry (VBM) [3]) using three-dimensional T1-weighted magnetic resonance images (3D-T1WIs) with spatial normalization have been used to estimate local brain volume in normal subjects [4 –7] and in patients (e.g., in Alzheimer’s disease (AD) [8], epilepsy[9], diabetes [10], and panic disorder [11])...

Spicamycin, a nucleoside antibiotic containing fatty acids with a variety of chain lengths (C12-C18), showed potent antitumor activity against human gastric cancer SC-9 and human breast cancer MX-1 in a xenograft model. We have made several semi-synthetic spicamycin analogues (SPMs) which differed in the chain length of the fatty acid moiety, and examined their structure-antitumor activity rela...

Presence of free air in the mediastinum without any identifiable cause is defined as spontaneous pneumomediastinum (SPM). SPM is more common in young males. The common inciting event leading to SPM are retching, vomiting, acute asthma attack, intense sport activity, inhalation of drugs and weight loss as seen in anorexia nervosa. Analgesics and rest is the mainstay of treatment. Recurrence of S...

The FIL Methods Group (and honorary members) This is SPM12 1 , a major update to the SPM software, containing substantial theoretical, algorithmic, structural and interface enhancements over previous versions, as detailed in this document. Although SPM12 will read image files from previous versions of SPM, there are differences in the algorithms, templates and models used. Therefore, we recomme...