Exploratory data analysis (EDA) is a well-established statistical tradition that provides conceptual and computational tools for discovering patterns to foster hypothesis development and refinement. These tools and attitudes complement the use of significance and hypothesis tests used in confirmatory data analysis (CDA). Although EDA complements rather than replaces CDA, use of CDA without EDA ...

It is widely accepted that evolutionary changes in conserved developmental signaling pathways play an important role in morphological evolution. However, few in silico studies were interested in tracking such changes in a signaling pathway. The Ectodysplasin (EDA) pathway provides an opportunity to fill this gap because it is involved in vertebrate skin appendage development such as scales, tee...

There has been growing interest in Estimation of Distribution Algorithms (EDA). Conventional EDA mainly use a linear string representation, resembling an individual of Genetic Algorithms (GA). Because of the flexibility of GP style tree encoding, a limited number of researchers have started addressing estimation of distribution of GP-style tree form solutions. For simplicity, we refer to this k...

Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells, thus signifying its importance in control of metastatic progression. In this ...

Mammary gland development commences during embryogenesis with the establishment of a species typical number of mammary primordia on each flank of the embryo. It is thought that mammary cell fate can only be induced along the mammary line, a narrow region of the ventro-lateral skin running from the axilla to the groin. Ectodysplasin (Eda) is a tumor necrosis factor family ligand that regulates m...

Electrodermal Activity (EDA) − an index of sympathetic nervous system arousal − is one of the primary methods used in psychophysiology to assess the autonomic nervous system [1]. While many studies collect EDA data in short, laboratory-based experiments, recent developments in wireless biosensing have enabled longer, ‘out-of-lab’ ambulatory studies to become more common [2]. Such ambulatory met...

Advances in donor matching and immunosuppressive therapies have decreased the prevalence of acute rejection of cardiac grafts; however, chronic rejection remains a significant obstacle for long-term allograft survival. While initiating elements of anti-allograft immune responses have been identified, the linkage between these factors and the ultimate development of cardiac fibrosis is not well ...

Pain is a complex experience with sensory, emotional and cognitive aspects. It also includes a sympathetic response that can be captured by measuring the electrodermal activity (EDA). The present study was performed to investigate which brain areas are associated with sympathetic activation in experimental pain; an issue that has not been addressed with fMRI (functional magnetic resonance imagi...

OBJECTIVES To provide an in-depth analysis of seven well-reported studies that examined electrodermal activity (EDA) at acupuncture points with regard to three commonly held tenets of acupuncture: (1) EDA at pathology-related acupuncture points is distinguishable from non-pathology-related acupuncture points; (2) EDA at acupuncture points can assist in diagnosing and monitoring therapeutic prog...

Keywords Random EDA, Mixture EDA