The efficacy of polydisulfide-based biodegradable macromolecular contrast agents for characterizing tumor angiogenesis was investigated in a mouse model using dynamic contrast-enhanced MRI (DCE-MRI). Biodegradable macromolecular MRI contrast agents, gadopentetate dimeglumine (Gd-DTPA) cystamine copolymers (GDCC), and Gd-DTPA cystine copolymers (GDCP), with molecular weights of 20 and 70 kDa wer...

The use of Gd-DTPA in nondegenerative spinal lesions is described. Thirty consecutive patients were examined by MR with and without Gd-DTPA. The information obtained with unenhanced T1- and T2-weighted spin-echo images was compared with that obtained with Gd-DTPA T1-weighted images. The results showed that, according to the criteria used, more information was present on the MR images with Gd-DT...

As technology is scaled down to 5 nm or even smaller, ruthenium (Ru) will most likely be chosen as the next generation barrier material for copper interconnects in integrated circuits (ICs). Recently, higher removal rate of Ru materials chemical mechanical polishing (CMP) has become a major issue. In this paper, diethylene triaminepentaacetic acid pentapotassium salt (DTPA-5K) was introduced ne...

INTRODUCTION L,L-ethylenedicysteine (EC) is a new carrier of technetium Tc 99m (99mTc) with a lower affinity to plasma albumin in comparison with diethylenetriamine pentaacetic acid (DTPA). We compared 99mTc-EC scan with 99mTc-DTPA scan in diuretic renography for patients with obstructive uropathy. MATERIALS AND METHODS Thirty-three patients with upper urinary tract obstruction were randomly ...

To test a two-step approach for radioimmunotargeting of renal cell cancer, quadroma cells secreting antichelate X anti-renal cell carcinoma bispecific antibodies were obtained by somatic cell fusion. Five monoclo­ nal antibodies against the chelate l,4,7-triazaheptane-A^N',/V"-pentaacetic acid (DTPA) were produced and characterized. Competitive binding assays indicated that the anti-DTPA antibo...

The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antib...

To test a two-step approach for radioimmunotargeting of renal cell cancer, quadroma cells secreting antichelate x anti-renal cell carcinoma bispecific antibodies were obtained by somatic cell fusion. Five monoclonal antibodies against the chelate 1,4,7-triazaheptane-N,N',N"-pentaacetic acid (DTPA) were produced and characterized. Competitive binding assays indicated that the anti-DTPA antibodie...

Biodegradable gadopentetic acid (Gd-DTPA)-loaded chitosan microparticles (Gd-microCPs) were prepared as a device for gadolinium neutron-capture therapy (Gd-NCT) by a novel emulsion-droplet coalescence technique: a water-in-oil (w/o) emulsion A containing chitosan and Gd-DTPA in droplets and a w/o emulsion B containing NaOH in droplets were mixed and stirred to solidify chitosan as a result of c...

A new method has been developed for conjugating diethylenetriaminepentaacetic acid (DTPA) to proteins using the N-hydroxysuccinimide active ester of DTPA. The DTPA-active ester was prepared using diisopropylcarbodiimide in a simple single step synthesis. DTPA-conjugated proteins were prepared by adding the DTPA-active ester reaction mixture to protein solutions (5 mg/ml) buffered at pH 7.0 and ...