INTRODUCTION Catheter-related infection is associated with increased all-cause mortality and morbidity in hemodialysis patients. This study aimed to evaluate an antimicrobial lock solution (cloxacillin and heparin) in temporary noncuffed double-lumen catheters for long-term intermittent hemodialysis as a method of preventing catheter-related infection. MATERIALS AND METHODS Patients on hemodi...

Objective: To determine whether high concentrations of antibiotic “locked” into a central venous catheter with heparin would retain sufficient antimicrobial activity to inhibit the growth of organisms commonly causing catheter-related infections in patients undergoing hemodialysis. Methods: Cefazolin, vancomycin, ceftazidime (all at final concentrations of 10 mg/mL), and gentamicin (final conce...